1-(1-cyclohexylethyl)-5-(3,5-di-tert-butylphenyl)-2-methyl-N-(oxetan-3-yl)-1H-pyrrole-3-carboxamide

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Chemical Name:1-(1-cyclohexylethyl)-5-(3,5-di-tert-butylphenyl)-2-methyl-N-(oxetan-3-yl)-1H-pyrrole-3-carboxamide
CAS No.:1442422-98-1
Molecular Formula:C₃₁H₄₆N₂O₂
Molecular Weight:478.718
Hs Code.:

Synonyms:1-(1-cyclohexylethyl)-5-(3,5-di-tert-butylphenyl)-2-methyl-N-(oxetan-3-yl)-1H-pyrrole-3-carboxamide

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Chemical Property of 1-(1-cyclohexylethyl)-5-(3,5-di-tert-butylphenyl)-2-methyl-N-(oxetan-3-yl)-1H-pyrrole-3-carboxamide

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Technology Process of 1-(1-cyclohexylethyl)-5-(3,5-di-tert-butylphenyl)-2-methyl-N-(oxetan-3-yl)-1H-pyrrole-3-carboxamide

There total 7 articles about 1-(1-cyclohexylethyl)-5-(3,5-di-tert-butylphenyl)-2-methyl-N-(oxetan-3-yl)-1H-pyrrole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 1442432-53-2
1-(1-cyclohexylethyl)-5-(3,5-di-tert-butylphenyl)-2-methyl-1H-pyrrole-3-carboxylic acid

: 21635-88-1
3-oxetanamine

: 1442422-98-1
1-(1-cyclohexylethyl)-5-(3,5-di-tert-butylphenyl)-2-methyl-N-(oxetan-3-yl)-1H-pyrrole-3-carboxamide

Guidance literature:: 1-(1-cyclohexylethyl)-5-(3,5-di-tert-butylphenyl)-2-methyl-1H-pyrrole-3-carboxylic acid; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; for 1h;

3-oxetanamine; In N,N-dimethyl-formamide;

Reference yield:

: 936-12-9
2-methyl-1H-pyrrole-3-carboxylic acid ethyl ester

: 1442422-98-1
1-(1-cyclohexylethyl)-5-(3,5-di-tert-butylphenyl)-2-methyl-N-(oxetan-3-yl)-1H-pyrrole-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

1.2: 12 h

2.1: N-Bromosuccinimide / tetrahydrofuran / 0.08 h / -78 °C / Inert atmosphere

3.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / 1,4-dioxane; water / 90 °C / Inert atmosphere

4.1: potassium hydroxide / ethanol / Reflux

5.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-Bromosuccinimide; sodium hydride; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 185030-33-5
1-cyclohexylethyl methanesulfonate

: 1442422-98-1
1-(1-cyclohexylethyl)-5-(3,5-di-tert-butylphenyl)-2-methyl-N-(oxetan-3-yl)-1H-pyrrole-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

1.2: 12 h

2.1: N-Bromosuccinimide / tetrahydrofuran / 0.08 h / -78 °C / Inert atmosphere

3.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / 1,4-dioxane; water / 90 °C / Inert atmosphere

4.1: potassium hydroxide / ethanol / Reflux

5.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-Bromosuccinimide; sodium hydride; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide; mineral oil;