(3RS,1'RS)-1-methyl-3-(1'-methyl-3'-oxo-3'-(2,4,6-triisoprpylphenyl)propyl)-2-thiopyrrolidinone

Base Information

Chemical Name:(3RS,1'RS)-1-methyl-3-(1'-methyl-3'-oxo-3'-(2,4,6-triisoprpylphenyl)propyl)-2-thiopyrrolidinone
CAS No.:122969-37-3
Molecular Formula:C₂₄H₃₇NOS
Molecular Weight:387.63
Hs Code.:

Synonyms:(3RS,1'RS)-1-methyl-3-(1'-methyl-3'-oxo-3'-(2,4,6-triisoprpylphenyl)propyl)-2-thiopyrrolidinone

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Chemical Property of (3RS,1'RS)-1-methyl-3-(1'-methyl-3'-oxo-3'-(2,4,6-triisoprpylphenyl)propyl)-2-thiopyrrolidinone

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Technology Process of (3RS,1'RS)-1-methyl-3-(1'-methyl-3'-oxo-3'-(2,4,6-triisoprpylphenyl)propyl)-2-thiopyrrolidinone

There total 5 articles about (3RS,1'RS)-1-methyl-3-(1'-methyl-3'-oxo-3'-(2,4,6-triisoprpylphenyl)propyl)-2-thiopyrrolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 122969-21-5
(3RS,1'RS)-1-methyl-3-(1'-methyl-3'-oxo-3'-(2,4,6-triisopropylphenyl)propyl)-2-pyrrolidinone

: 122969-37-3
(3RS,1'RS)-1-methyl-3-(1'-methyl-3'-oxo-3'-(2,4,6-triisoprpylphenyl)propyl)-2-thiopyrrolidinone

Guidance literature:: With Lawessons reagent; In tetrahydrofuran; for 24h;
DOI:10.1021/jo00288a027

Reference yield:

: 122968-43-8
(E)-1-(2,4,6-triisopropylphenyl)-2-buten-1-one

: 10441-57-3
1-methyl-pyrrolidine-2-thione

: 122969-37-3
(3RS,1'RS)-1-methyl-3-(1'-methyl-3'-oxo-3'-(2,4,6-triisoprpylphenyl)propyl)-2-thiopyrrolidinone

: 122969-38-4
(3RS,1'SR)-1-methyl-3-(1'-methyl-3'-oxo-3'-(2,4,6-triisopropylphenyl)propyl)-2-thiopyrrolidinone

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 3h; Yield given. Yields of byproduct given;
DOI:10.1021/jo00288a027

Reference yield:

: 717-74-8
1,3,5-triisopropyl benzene

: 122969-37-3
(3RS,1'RS)-1-methyl-3-(1'-methyl-3'-oxo-3'-(2,4,6-triisoprpylphenyl)propyl)-2-thiopyrrolidinone

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / AlCl₃ / CS₂ / Heating

2: LDA / tetrahydrofuran / 4 h / -78 °C

3: 63 percent / Lawessons's reagent / tetrahydrofuran / 24 h

With Lawessons reagent; aluminium trichloride; lithium diisopropyl amide; In tetrahydrofuran; carbon disulfide;
DOI:10.1021/jo00288a027