Technology Process of 2-diazo-5-hydroxy-1-phenyl-5-(thiophene-2-yl)pentane-1,3-dione
There total 2 articles about 2-diazo-5-hydroxy-1-phenyl-5-(thiophene-2-yl)pentane-1,3-dione which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-diazo-1-phenylbutane-1,3-dione;
With
titanium tetrachloride; triethylamine;
In
dichloromethane;
at -78 ℃;
for 1h;
Inert atmosphere;
thiophene-2-carbaldehyde;
In
dichloromethane;
at -78 ℃;
for 4h;
Inert atmosphere;
DOI:10.1021/jo400989q
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: triethylamine; 4-acetamidobenzenesulfonyl azide / acetonitrile / 2 h / 0 - 20 °C / Inert atmosphere
2.1: titanium tetrachloride; triethylamine / dichloromethane / 1 h / -78 °C / Inert atmosphere
2.2: 4 h / -78 °C / Inert atmosphere
With
4-acetamidobenzenesulfonyl azide; titanium tetrachloride; triethylamine;
In
dichloromethane; acetonitrile;
1.1: |Regitz Diazo Transfer;
DOI:10.1021/jo400989q
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / acetonitrile / 2 h / Inert atmosphere; Reflux
2: tributylphosphine / di-isopropyl ether / 0.5 h / 20 °C / Inert atmosphere
3: trichlorophosphate / 4 h / 95 °C
4: hydroxylamine hydrochloride; pyridine / ethanol / 16 h / Reflux
5: sodium hydride / tetrahydrofuran / 2 h / 20 - 40 °C / Inert atmosphere
With
pyridine; tributylphosphine; hydroxylamine hydrochloride; sodium hydride; trichlorophosphate; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione;
In
tetrahydrofuran; ethanol; di-isopropyl ether; acetonitrile;
DOI:10.1021/jo400989q
