4-(1-methyl-1H-pyrrolo[3,2-b]quinolin-3-yl)phenol

Base Information

Chemical Name:4-(1-methyl-1H-pyrrolo[3,2-b]quinolin-3-yl)phenol
CAS No.:1620086-92-1
Molecular Formula:C₁₈H₁₄N₂O
Molecular Weight:274.322
Hs Code.:

Synonyms:4-(1-methyl-1H-pyrrolo[3,2-b]quinolin-3-yl)phenol

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Chemical Property of 4-(1-methyl-1H-pyrrolo[3,2-b]quinolin-3-yl)phenol

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Technology Process of 4-(1-methyl-1H-pyrrolo[3,2-b]quinolin-3-yl)phenol

There total 6 articles about 4-(1-methyl-1H-pyrrolo[3,2-b]quinolin-3-yl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1620098-22-7
1-methyl-3-[4-(tetrahydro-2H-pyran-2-yloxy)phenyl]-1H-pyrrolo[3,2-b]quinoline

: 1620086-92-1
4-(1-methyl-1H-pyrrolo[3,2-b]quinolin-3-yl)phenol

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; methanol; water; at 0 ℃; for 0.5h; Inert atmosphere; Schlenk technique;
DOI:10.1016/j.bmcl.2014.06.028

Reference yield:

: 742698-74-4
tert-butyl (2-chloroquinolin-3-yl)carbamate

: 1620086-92-1
4-(1-methyl-1H-pyrrolo[3,2-b]quinolin-3-yl)phenol

Guidance literature:: Multi-step reaction with 4 steps

1.1: trifluoroacetic acid / 1,2-dichloro-ethane / 0 - 20 °C / Inert atmosphere; Schlenk technique

2.1: potassium acetate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri tert-butylphosphoniumtetrafluoroborate / N,N-dimethyl acetamide / 16 h / 120 °C / Inert atmosphere; Schlenk technique

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C / Inert atmosphere; Schlenk technique

3.2: 1 h / 20 °C / Inert atmosphere; Schlenk technique

4.1: hydrogenchloride / tetrahydrofuran; methanol; water / 0.5 h / 0 °C / Inert atmosphere; Schlenk technique

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium acetate; sodium hydride; trifluoroacetic acid; tri tert-butylphosphoniumtetrafluoroborate; In tetrahydrofuran; methanol; N,N-dimethyl acetamide; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.bmcl.2014.06.028

Reference yield:

: 116632-54-3
2-chloro-3-aminoquinoline

: 1620086-92-1
4-(1-methyl-1H-pyrrolo[3,2-b]quinolin-3-yl)phenol

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium acetate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri tert-butylphosphoniumtetrafluoroborate / N,N-dimethyl acetamide / 16 h / 120 °C / Inert atmosphere; Schlenk technique

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C / Inert atmosphere; Schlenk technique

2.2: 1 h / 20 °C / Inert atmosphere; Schlenk technique

3.1: hydrogenchloride / tetrahydrofuran; methanol; water / 0.5 h / 0 °C / Inert atmosphere; Schlenk technique

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium acetate; sodium hydride; tri tert-butylphosphoniumtetrafluoroborate; In tetrahydrofuran; methanol; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.bmcl.2014.06.028