2-Amino-1-pyrroline hydrochloride

Base Information

• Chemical Name: 2-Amino-1-pyrroline hydrochloride
• CAS No.: 7544-75-4
• Molecular Formula: C4H9ClN2
• Molecular Weight: 120.582
• Hs Code.: 2933990090
• Mol file: 7544-75-4.mol

Synonyms:2H-Pyrrol-5-amine,3,4-dihydro-, monohydrochloride (9CI);Pyrrolidine, 2-imino-, monohydrochloride(8CI);2-Iminopyrrolidine hydrochloride;3,4-dihydro-2H-pyrrol-5-amine hydrochloride (1:1);2-Amino-1-pyrroline hydrochloride;

Chemical Property of 2-Amino-1-pyrroline hydrochloride

Chemical Property:

• Vapor Pressure: 0.155mmHg at 25°C
• Melting Point: 171.0 to 175.0 °C
• Boiling Point: 211 °C at 760 mmHg
• Flash Point: 81.4 °C
• PSA: 38.38000
• LogP: 1.07530
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

95.0%+ ^*data from raw suppliers

pyrrolidin-2-iminehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Amino-1-pyrroline hydrochloride

There total 5 articles about 2-Amino-1-pyrroline hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

2-pyrrolidinon (616-45-5) → 2-iminopyrrolidine-hydrochloride (7544-75-4)

Guidance literature:

2-pyrrolidinon; With dimethyl sulfate; at 25 - 65 ℃;

With ammonium chloride; In dichloromethane; at 25 - 35 ℃;

Reference yield: 40.0%

4-Chlorobutyronitrile (628-20-6) → 2-iminopyrrolidine-hydrochloride (7544-75-4)

Guidance literature:

With ammonia; In ethanol; at -78 - 120 ℃; for 16.75h; Autoclave;

Reference yield:

2-Methoxypyrroline (66996-69-8) → 2-iminopyrrolidine-hydrochloride (7544-75-4)

Guidance literature:

With ammonium chloride; In ethanol;

DOI:10.1021/jm010493y

upstream raw materials:

2-Methoxypyrroline

4-Chlorobutyronitrile

2-pyrrolidinon

2-methoxy-1-pyrroline

Downstream raw materials:

C₁₂H₁₅N₃O₃S

C₁₁H₁₂ClN₃O₃S

C₁₁H₁₃N₃O₃S

Tipiracil

Refernces

• 1、 -. "NOVEL INHIBITOR COMPOUNDS OF PHOSPHODIESTERASE TYPE 10A". Paragraph 0354-0355. . Retrieved 2014/06/11.
• 2、 Callahan, James F.,Burgess, Joelle L.,Fornwald, James A.,Gaster, Laramie M.,Harling, John D.,Harrington, Frank P.,Heer, Jag,Kwon, Chet,Lehr, Ruth,Mathur,Olson, Barbara A.,Weinstock, Joseph,Laping, Nicholas J.. "Identification of novel inhibitors of the transforming growth factor β1 (TGF-β1) type 1 receptor (ALK5)". . p. 999 - 1001. Retrieved 2007/10/03.