Technology Process of 2-(4-aminobenzyl)-2-methylmalonamide
There total 5 articles about 2-(4-aminobenzyl)-2-methylmalonamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
palladium 10% on activated carbon; hydrogen;
In
ethanol; ethyl acetate;
for 6h;
under 760.051 Torr;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C
1.2: 19 h
2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C
2.2: 21 h / 0 - 20 °C
3.1: lithium hydroxide monohydrate; water / 1,4-dioxane / 22 h / 50 °C
4.1: oxalyl dichloride; N,N-dimethyl-formamide / 1,4-dioxane; dichloromethane / 4 h / 0 °C
4.2: 15 h / 0 °C
5.1: palladium 10% on activated carbon; hydrogen / ethanol; ethyl acetate / 6 h / 760.05 Torr
With
oxalyl dichloride; lithium hydroxide monohydrate; palladium 10% on activated carbon; water; hydrogen; sodium hydride; N,N-dimethyl-formamide;
In
1,4-dioxane; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; mineral oil;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: lithium hydroxide monohydrate; water / 1,4-dioxane / 22 h / 50 °C
2.1: oxalyl dichloride; N,N-dimethyl-formamide / 1,4-dioxane; dichloromethane / 4 h / 0 °C
2.2: 15 h / 0 °C
3.1: palladium 10% on activated carbon; hydrogen / ethanol; ethyl acetate / 6 h / 760.05 Torr
With
oxalyl dichloride; lithium hydroxide monohydrate; palladium 10% on activated carbon; water; hydrogen; N,N-dimethyl-formamide;
In
1,4-dioxane; ethanol; dichloromethane; ethyl acetate;
