8-((3R,4S)-4-ethylpyrrolidin-3-yl)-3-tosyl-3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazine

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Chemical Name:8-((3R,4S)-4-ethylpyrrolidin-3-yl)-3-tosyl-3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazine
CAS No.:1428243-28-0
Molecular Formula:C₂₁H₂₃N₅O₂S
Molecular Weight:409.512
Hs Code.:
Mol file:1428243-28-0.mol

Synonyms:8-((3R,4S)-4-ethylpyrrolidin-3-yl)-3-tosyl-3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazine

Suppliers and Price of 8-((3R,4S)-4-ethylpyrrolidin-3-yl)-3-tosyl-3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 8-((3R,4S)-4-ethylpyrrolidin-3-yl)-3-tosyl-3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazine Edit

Chemical Property:

Density:1.45±0.1 g/cm3(Predicted)

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of 8-((3R,4S)-4-ethylpyrrolidin-3-yl)-3-tosyl-3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazine

There total 15 articles about 8-((3R,4S)-4-ethylpyrrolidin-3-yl)-3-tosyl-3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: (3S,4R)-benzyl 3-ethyl-4-(3-tosyl-3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)pyrrolidine-1-carboxylate

: 1428243-28-0
8-((3R,4S)-4-ethylpyrrolidin-3-yl)-3-tosyl-3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazine

Guidance literature:: With hydrogenchloride; In water; isopropyl alcohol; at 20 - 80 ℃; for 5h;

Reference yield:

: 1428243-26-8
(3R,4S)-benzyl 3-(2-bromoacetyl)-4-ethylpyrrolidine-1-carboxylate

: 1428243-28-0
8-((3R,4S)-4-ethylpyrrolidin-3-yl)-3-tosyl-3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazine

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 1.5 h / 0 °C

1.2: 1 h / 0 °C

2.1: trifluoroacetic acid / dichloromethane / 4 h / 5 - 27 °C

3.1: Lawessons reagent / toluene; 1,4-dioxane / 4 h / 27 - 80 °C / Inert atmosphere

4.1: acetic acid; hydrogen bromide / 1,4-dioxane / 3 h / 27 - 60 °C

With Lawessons reagent; hydrogen bromide; sodium hydride; acetic acid; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 1428243-27-9
(3R,4S)-benzyl 3-(2-(tert-butoxycarbonyl(5-tosyl-5H-pyrrolo[2,3-b]pyrazin-2-yl)amino)acetyl)-4-ethylpyrrolidine-1-carboxylate

: 1428243-28-0
8-((3R,4S)-4-ethylpyrrolidin-3-yl)-3-tosyl-3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazine

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / dichloromethane / 4 h / 5 - 27 °C

2: Lawessons reagent / toluene; 1,4-dioxane / 4 h / 27 - 80 °C / Inert atmosphere

3: acetic acid; hydrogen bromide / 1,4-dioxane / 3 h / 27 - 60 °C

With Lawessons reagent; hydrogen bromide; acetic acid; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; toluene;