(3R,4S)-3-(2-Bromoacetyl)-4-ethyl-1-pyrrolidinecarboxylic acid phenylmethyl ester

Base Information

• Chemical Name: (3R,4S)-3-(2-Bromoacetyl)-4-ethyl-1-pyrrolidinecarboxylic acid phenylmethyl ester
• CAS No.: 1428243-26-8
• Molecular Formula: C₁₆H₂₀BrNO₃
• Molecular Weight: 354.244
• Mol file: 1428243-26-8.mol

Synonyms:(3R,4S)-benzyl 3-(2-bromoacetyl)-4-ethylpyrrolidine-1-carboxylate

Chemical Property of (3R,4S)-3-(2-Bromoacetyl)-4-ethyl-1-pyrrolidinecarboxylic acid phenylmethyl ester

Chemical Property:

• Boiling Point: 453.1±45.0 °C(Predicted)
• PKA: -2.91±0.60(Predicted)
• Density: 1.361±0.06 g/cm3(Predicted)

Purity/Quality:

98.0%, ^*data from raw suppliers

benzyl(3R,4S)-3-(2-bromoacetyl)-4-ethylpyrrolidine-1-carboxylate 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: (3R,4S)-3-(2-Bromoacetyl)-4-ethylpyrrolidine-1-carboxylate is a reagent in the preparation of imidazopyrrolopyrazine derivatives and analogs for use as protein kinase modulators.

Technology Process of (3R,4S)-3-(2-Bromoacetyl)-4-ethyl-1-pyrrolidinecarboxylic acid phenylmethyl ester

There total 56 articles about (3R,4S)-3-(2-Bromoacetyl)-4-ethyl-1-pyrrolidinecarboxylic acid phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

C15H18ClNO3 + diazomethyl-trimethyl-silane (18107-18-1) → (3R,4S)-benzyl 3-(2-bromoacetyl)-4-ethylpyrrolidine-1-carboxylate (1428243-26-8)

Guidance literature:

C₁₅H₁₈ClNO₃; diazomethyl-trimethyl-silane; In tetrahydrofuran; diethyl ether; acetonitrile; at -10 - 10 ℃; for 2h;

With hydrogen bromide; In tetrahydrofuran; diethyl ether; water; acetonitrile; at 10 ℃; for 4h;

Reference yield: 89.9%

N-methyl-N-nitroso-p-toluenesulfonamide (23114-01-4) + C15H18ClNO3 → (3R,4S)-benzyl 3-(2-bromoacetyl)-4-ethylpyrrolidine-1-carboxylate (1428243-26-8)

Guidance literature:

With hydrogen bromide; potassium hydroxide; In tetrahydrofuran; water; dimethyl sulfoxide; at 25 - 30 ℃; for 0.394833h; Solvent; Temperature;

Reference yield: 83.0%

C21H25NO7 → (3R,4S)-benzyl 3-(2-bromoacetyl)-4-ethylpyrrolidine-1-carboxylate (1428243-26-8)

Guidance literature:

C₂₁H₂₅NO₇; With bromine; acetic anhydride; acetic acid; at 0 - 20 ℃;

With sulfuric acid; at 20 ℃;

upstream raw materials:

ethyl pent-2-ynoate

(cis)-2-pentenoic acid ethyl ester

(3R,4S)-1-((benzyloxy)carbonyl)-4-ethylpyrrolidine-3-carboxylic acid (R)-1-(naphthalen-1-yl)ethan-1-amine salt

diazomethyl-trimethyl-silane

Downstream raw materials:

(3R,4S)-benzyl 3-(2-(tert-butoxycarbonyl(5-tosyl-5H-pyrrolo[2,3-b]pyrazin-2-yl)amino)acetyl)-4-ethylpyrrolidine-1-carboxylate

(3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide

8-((3R,4S)-4-ethylpyrrolidin-3-yl)-3-tosyl-3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazine