methyl (3R,4R,5S,6S,7R)-3,5,7-trihydroxy-6-methoxy-4-[(methylsulfonyl)oxy]-7-phenylheptanoate

Base Information

Chemical Name:methyl (3R,4R,5S,6S,7R)-3,5,7-trihydroxy-6-methoxy-4-[(methylsulfonyl)oxy]-7-phenylheptanoate
CAS No.:1418193-76-6
Molecular Formula:C₁₆H₂₄O₉S
Molecular Weight:392.427
Hs Code.:

Synonyms:methyl (3R,4R,5S,6S,7R)-3,5,7-trihydroxy-6-methoxy-4-[(methylsulfonyl)oxy]-7-phenylheptanoate

Suppliers and Price of methyl (3R,4R,5S,6S,7R)-3,5,7-trihydroxy-6-methoxy-4-[(methylsulfonyl)oxy]-7-phenylheptanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl (3R,4R,5S,6S,7R)-3,5,7-trihydroxy-6-methoxy-4-[(methylsulfonyl)oxy]-7-phenylheptanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl (3R,4R,5S,6S,7R)-3,5,7-trihydroxy-6-methoxy-4-[(methylsulfonyl)oxy]-7-phenylheptanoate

There total 7 articles about methyl (3R,4R,5S,6S,7R)-3,5,7-trihydroxy-6-methoxy-4-[(methylsulfonyl)oxy]-7-phenylheptanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 67-56-1
methanol

: 1418193-74-4
methyl 2-((4R,5R,6R)-6-{(1R,2R)-2-[(tert-butyldimethylsilyl)oxy]-1-methoxy-2-phenylethyl}-2,2-dimethyl-5-[(methylsulfonyl)oxy]-1,3-dioxan-4-yl)acetate

: 1418193-76-6
methyl (3R,4R,5S,6S,7R)-3,5,7-trihydroxy-6-methoxy-4-[(methylsulfonyl)oxy]-7-phenylheptanoate

Guidance literature:: methanol; methyl 2-((4R,5R,6R)-6-{(1R,2R)-2-[(tert-butyldimethylsilyl)oxy]-1-methoxy-2-phenylethyl}-2,2-dimethyl-5-[(methylsulfonyl)oxy]-1,3-dioxan-4-yl)acetate; With sulfuric acid; In tetrahydrofuran; at 20 ℃;

With water; calcium carbonate; In tetrahydrofuran;
DOI:10.1055/s-0032-1316803

Reference yield:

: 1418193-72-2
methyl 2-((4R,6S)-6-{(1R,2R)-2-[(tert-butyldimethylsilyl)oxy]-1-methoxy-2-phenylethyl}-2,2-dimethyl-5-oxo-1,3-dioxan-4-yl)acetate

: 1418193-76-6
methyl (3R,4R,5S,6S,7R)-3,5,7-trihydroxy-6-methoxy-4-[(methylsulfonyl)oxy]-7-phenylheptanoate

Guidance literature:: Multi-step reaction with 3 steps

1: zinc(II) tetrahydroborate / diethyl ether / 10 h / -78 - 20 °C / Inert atmosphere

2: triethylamine; dmap / dichloromethane / 2.5 h / 0 - 20 °C

3: sulfuric acid / tetrahydrofuran / 20 °C

With dmap; zinc(II) tetrahydroborate; sulfuric acid; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1055/s-0032-1316803

Reference yield:

: (2R)-N-((R)-4-{(1R,2R)-2-[(tert-butyldimethylsilyl)oxy]-1-methoxy-2-phenylethyl}-2,2-dimethyl-1,3-dioxan-5-ylidene)-2-(methoxymethyl)cyclopentanamine

: 1418193-76-6
methyl (3R,4R,5S,6S,7R)-3,5,7-trihydroxy-6-methoxy-4-[(methylsulfonyl)oxy]-7-phenylheptanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: tert.-butyl lithium / tetrahydrofuran; pentane / 2 h / -78 °C / Inert atmosphere

1.2: 17 h / -100 - 20 °C / Inert atmosphere

2.1: ozone / dichloromethane / 0.25 h / -78 °C / Inert atmosphere

3.1: zinc(II) tetrahydroborate / diethyl ether / 10 h / -78 - 20 °C / Inert atmosphere

4.1: triethylamine; dmap / dichloromethane / 2.5 h / 0 - 20 °C

5.1: sulfuric acid / tetrahydrofuran / 20 °C

With dmap; zinc(II) tetrahydroborate; sulfuric acid; tert.-butyl lithium; ozone; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; pentane;
DOI:10.1055/s-0032-1316803