1-ethyl-2-(4-triisopropylsiloxyphenyl)-5-triisopropylsiloxy-3H-indene

Base Information

• Chemical Name: 1-ethyl-2-(4-triisopropylsiloxyphenyl)-5-triisopropylsiloxy-3H-indene
• CAS No.: 866021-05-8
• Molecular Formula: C₃₅H₅₆O₂Si₂
• Molecular Weight: 564.999
• Mol file: 866021-05-8.mol

Synonyms:1-ethyl-2-(4-triisopropylsiloxyphenyl)-5-triisopropylsiloxy-3H-indene

Chemical Property of 1-ethyl-2-(4-triisopropylsiloxyphenyl)-5-triisopropylsiloxy-3H-indene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-ethyl-2-(4-triisopropylsiloxyphenyl)-5-triisopropylsiloxy-3H-indene

There total 6 articles about 1-ethyl-2-(4-triisopropylsiloxyphenyl)-5-triisopropylsiloxy-3H-indene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

triisopropylsilyl chloride (13154-24-0) + 3-ethyl-2-(4-hydroxy-phenyl)-inden-6-ol (120551-19-1) → 1-ethyl-2-(4-triisopropylsiloxyphenyl)-5-triisopropylsiloxy-3H-indene (866021-05-8)

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; at 25 ℃; for 3.5h;

DOI:10.1021/jm050226i

Reference yield:

2-ethyl-3-(4-methoxyphenyl)oxirane-2-carboxylic acid (769073-61-2) → 1-ethyl-2-(4-triisopropylsiloxyphenyl)-5-triisopropylsiloxy-3H-indene (866021-05-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 11.553 g / 5 h / 60 - 100 °C

2.1: NaH / tetrahydrofuran; hexane / 3 h / 25 °C

2.2: 100 percent / tetrahydrofuran; hexane / 14 h / 25 °C

3.1: 55 percent / BBr₃ / CH₂Cl₂ / 7.5 h / -78 - 25 °C

4.1: 81 percent / imidazole / dimethylformamide / 3.5 h / 25 °C

With 1H-imidazole; boron tribromide; sodium hydride; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm050226i

Reference yield:

1-(3-methoxyphenyl)-2-(4-methoxyphenyl)pentan-3-one (866021-04-7) → 1-ethyl-2-(4-triisopropylsiloxyphenyl)-5-triisopropylsiloxy-3H-indene (866021-05-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 55 percent / BBr₃ / CH₂Cl₂ / 7.5 h / -78 - 25 °C

2: 81 percent / imidazole / dimethylformamide / 3.5 h / 25 °C

With 1H-imidazole; boron tribromide; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm050226i

upstream raw materials:

triisopropylsilyl chloride

3-ethyl-2-(4-hydroxy-phenyl)-inden-6-ol

2-ethyl-3-(4-methoxyphenyl)oxirane-2-carboxylic acid

1-(3-methoxyphenyl)-2-(4-methoxyphenyl)pentan-3-one

Downstream raw materials:

(+/-)-3-ethyl-6-triisopropylsiloxy-2-(4-triisopropylsiloxyphenyl)-1H-indene-1-carboxylic acid

(+/-)-1,3-diethyl-2-(4-triisopropylsiloxyphenyl)-5-triisopropylsiloxy-3H-indene

Ethyl indenestrol A

(+/-)-N-(4-(2-(dimethylamino)ethoxy)phenyl)-3-ethyl-6-triisopropylsiloxy-2-(4-triisopropylsiloxyphenyl)-1H-indene-1-carboxamide