4-nitrobenzenesulfonic acid (3R)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl ester

Base Information

Chemical Name:4-nitrobenzenesulfonic acid (3R)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl ester
CAS No.:608148-63-6
Molecular Formula:C₁₆H₁₄N₂O₆S
Molecular Weight:362.363
Hs Code.:

Synonyms:4-nitrobenzenesulfonic acid (3R)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl ester

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Chemical Property of 4-nitrobenzenesulfonic acid (3R)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl ester

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Technology Process of 4-nitrobenzenesulfonic acid (3R)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl ester

There total 6 articles about 4-nitrobenzenesulfonic acid (3R)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 577-59-3
2-acetylnitrobenzene

: 608148-63-6
4-nitrobenzenesulfonic acid (3R)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 99 percent / sodium ethoxide / tetrahydrofuran / 2 h / 0 °C

2.1: phenacyl chloride; baker's yeast / diethyl ether; H₂O / 24 h / 30 °C

3.1: H₂; HCl / Pd/C / methanol / 20 °C

3.2: 42 percent / AcOH / toluene / 80 °C

4.1: Et₃N / tetrahydrofuran / 16 h / 20 °C

With hydrogenchloride; baker's yeast; hydrogen; sodium ethanolate; 1-chloroacetophenone; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; water;
DOI:10.1016/S0957-4166(03)00453-1

Reference yield:

: 178114-28-8
4-(2-nitrophenyl)-2,4-dioxobutanoic acid ethyl ester

: 608148-63-6
4-nitrobenzenesulfonic acid (3R)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: phenacyl chloride; baker's yeast / diethyl ether; H₂O / 24 h / 30 °C

2.1: H₂; HCl / Pd/C / methanol / 20 °C

2.2: 42 percent / AcOH / toluene / 80 °C

3.1: Et₃N / tetrahydrofuran / 16 h / 20 °C

With hydrogenchloride; baker's yeast; hydrogen; 1-chloroacetophenone; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; water;
DOI:10.1016/S0957-4166(03)00453-1

Reference yield:

: 608148-58-9
(2R)-2-hydroxy-4-(2-nitrophenyl)-4-oxobutyric acid ethyl ester

: 608148-63-6
4-nitrobenzenesulfonic acid (3R)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: H₂; HCl / Pd/C / methanol / 20 °C

1.2: 42 percent / AcOH / toluene / 80 °C

2.1: Et₃N / tetrahydrofuran / 16 h / 20 °C

With hydrogenchloride; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol;
DOI:10.1016/S0957-4166(03)00453-1