N-(3-((benzyloxycarbonyl)amino)propyl)-(2S,4S,5S)-5-amino-6-cyclohexyl-4-hydroxy-2-isopropylhexanamide

Base Information

Chemical Name:N-(3-((benzyloxycarbonyl)amino)propyl)-(2S,4S,5S)-5-amino-6-cyclohexyl-4-hydroxy-2-isopropylhexanamide
CAS No.:142688-54-8
Molecular Formula:C₂₆H₄₃N₃O₄
Molecular Weight:461.645
Hs Code.:

Synonyms:N-(3-((benzyloxycarbonyl)amino)propyl)-(2S,4S,5S)-5-amino-6-cyclohexyl-4-hydroxy-2-isopropylhexanamide

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Chemical Property of N-(3-((benzyloxycarbonyl)amino)propyl)-(2S,4S,5S)-5-amino-6-cyclohexyl-4-hydroxy-2-isopropylhexanamide

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Technology Process of N-(3-((benzyloxycarbonyl)amino)propyl)-(2S,4S,5S)-5-amino-6-cyclohexyl-4-hydroxy-2-isopropylhexanamide

There total 4 articles about N-(3-((benzyloxycarbonyl)amino)propyl)-(2S,4S,5S)-5-amino-6-cyclohexyl-4-hydroxy-2-isopropylhexanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: {3-[(S)-2-((4S,5S)-4-Cyclohexylmethyl-2,2-dimethyl-oxazolidin-5-ylmethyl)-3-methyl-butyrylamino]-propyl}-carbamic acid benzyl ester

: 142688-54-8
N-(3-((benzyloxycarbonyl)amino)propyl)-(2S,4S,5S)-5-amino-6-cyclohexyl-4-hydroxy-2-isopropylhexanamide

Guidance literature:: With water; In tetrahydrofuran; at 0 ℃; for 18h;
DOI:10.1021/jm00045a003

Reference yield:

: 46460-73-5
N-benzyloxycarbonyl-1,3-diaminopropane

: 142688-54-8
N-(3-((benzyloxycarbonyl)amino)propyl)-(2S,4S,5S)-5-amino-6-cyclohexyl-4-hydroxy-2-isopropylhexanamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) HOBt hydrate, 4-methylmorpholine, 2.) EDC / 1.) DMF, -20 deg C, 2.)a) DMF, -20 deg C, 4 h, b) RT, 16 h

2: trifluoroacetic acid / CH₂Cl₂ / 4 h / 0 °C

3: H₂O / tetrahydrofuran / 18 h / 0 °C

With 4-methyl-morpholine; water; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm00045a003

Reference yield:

: 129921-93-3
2-(S)-((3-(tert-butyloxycarbonyl)-2,2-dimethyl-4(S)-(cyclohexylmethyl)-5(S)-oxazolidinyl)methyl)-3-methylbutanoic acid

: 142688-54-8
N-(3-((benzyloxycarbonyl)amino)propyl)-(2S,4S,5S)-5-amino-6-cyclohexyl-4-hydroxy-2-isopropylhexanamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) HOBt hydrate, 4-methylmorpholine, 2.) EDC / 1.) DMF, -20 deg C, 2.)a) DMF, -20 deg C, 4 h, b) RT, 16 h

2: trifluoroacetic acid / CH₂Cl₂ / 4 h / 0 °C

3: H₂O / tetrahydrofuran / 18 h / 0 °C

With 4-methyl-morpholine; water; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm00045a003