4<<4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridin-2-yl>methoxy>-2-butynoic acid

Base Information

Chemical Name:4<<4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridin-2-yl>methoxy>-2-butynoic acid
CAS No.:101411-64-7
Molecular Formula:C₂₂H₂₁Cl₂NO₇
Molecular Weight:482.317
Hs Code.:

Synonyms:4<<4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridin-2-yl>methoxy>-2-butynoic acid

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Chemical Property of 4<<4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridin-2-yl>methoxy>-2-butynoic acid

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Technology Process of 4<<4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridin-2-yl>methoxy>-2-butynoic acid

There total 6 articles about 4<<4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridin-2-yl>methoxy>-2-butynoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 101411-65-8
1-<<4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridin-2-yl>methoxy>-2-propyne

: 101411-64-7
4<<4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridin-2-yl>methoxy>-2-butynoic acid

Guidance literature:: With n-butyllithium; carbon dioxide; In tetrahydrofuran; hexane;

Reference yield:

: 124-38-9,18923-20-1
carbon dioxide

: 101411-65-8
1-<<4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridin-2-yl>methoxy>-2-propyne

: 101411-64-7
4<<4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridin-2-yl>methoxy>-2-butynoic acid

Guidance literature:: With n-butyllithium; Multistep reaction; 1.) THF, hHexane, from -70 deg C to -10 deg C, 2.) THF, hexane, -40 deg C, 1 h;
DOI:10.1016/0223-5234(91)90197-U

Reference yield:

: 638-07-3
ethyl (2-chloroaceto)acetate

: 101411-64-7
4<<4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridin-2-yl>methoxy>-2-butynoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 1) NaH / 1) THF, oil, ice cooling, 2) THF, 16 h

2: 1) piperidine / 1) 2-propanol, 24 h, 2) 4 d

3: 1) nBuLi / 1) hexane, THF, -65 deg C, 2.5 h, 2) 2 h, to 0 deg C

With piperidine; n-butyllithium; sodium hydride;
DOI:10.1021/jm00130a026