(5'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3'H-spiro[azetidine-3,1'-isobenzofuran]-1-yl)(1-oxidothietan-3-yl)methanone

Base Information

Chemical Name:(5'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3'H-spiro[azetidine-3,1'-isobenzofuran]-1-yl)(1-oxidothietan-3-yl)methanone
CAS No.:1398608-95-1
Molecular Formula:C₂₄H₁₈Cl₂F₄N₂O₄S
Molecular Weight:577.384
Hs Code.:

(5'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3'H-spiro[azetidine-3,1'-isobenzofuran]-1-yl)(1-oxidothietan-3-yl)methanone

Synonyms:(5'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3'H-spiro[azetidine-3,1'-isobenzofuran]-1-yl)(1-oxidothietan-3-yl)methanone

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Chemical Property of (5'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3'H-spiro[azetidine-3,1'-isobenzofuran]-1-yl)(1-oxidothietan-3-yl)methanone

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Technology Process of (5'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3'H-spiro[azetidine-3,1'-isobenzofuran]-1-yl)(1-oxidothietan-3-yl)methanone

There total 5 articles about (5'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3'H-spiro[azetidine-3,1'-isobenzofuran]-1-yl)(1-oxidothietan-3-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 766-14-3,13129-19-6
thietane-3-carboxylic acid 1-oxide

: 1398609-72-7
5'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3'H-spiro[azetidine-3,1'-isobenzofuran]

: 1398608-95-1
(5'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3'H-spiro[azetidine-3,1'-isobenzofuran]-1-yl)(1-oxidothietan-3-yl)methanone

Guidance literature:: thietane-3-carboxylic acid 1-oxide; With 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h;

5'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3'H-spiro[azetidine-3,1'-isobenzofuran]; With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

Reference yield:

: 1398609-68-1
1-benzhydryl-3-(2-bromo-4-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)phenyl)azetidin-3-ol

: 1398608-95-1
(5'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3'H-spiro[azetidine-3,1'-isobenzofuran]-1-yl)(1-oxidothietan-3-yl)methanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 12 h / 85 °C

2.1: lithium borohydride / tetrahydrofuran / 16 h / 20 °C

3.1: triethylamine; p-toluenesulfonylanhydride / toluene / 16 h / 0 - 20 °C

4.1: carbonochloridic acid 1-chloro-ethyl ester / acetonitrile / 2 h / 75 °C

4.2: 1 h / Reflux

5.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 0.25 h / 20 °C

5.2: 18 h / 20 °C

With lithium borohydride; carbonochloridic acid 1-chloro-ethyl ester; p-toluenesulfonylanhydride; palladium diacetate; triethylamine; 1,1'-carbonyldiimidazole; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 1398609-70-5
1-benzhydryl-3-(2-hydroxymethyl-4-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)phenyl)azetidin-3-ol

: 1398608-95-1
(5'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3'H-spiro[azetidine-3,1'-isobenzofuran]-1-yl)(1-oxidothietan-3-yl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; p-toluenesulfonylanhydride / toluene / 16 h / 0 - 20 °C

2.1: carbonochloridic acid 1-chloro-ethyl ester / acetonitrile / 2 h / 75 °C

2.2: 1 h / Reflux

3.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 0.25 h / 20 °C

3.2: 18 h / 20 °C

With carbonochloridic acid 1-chloro-ethyl ester; p-toluenesulfonylanhydride; triethylamine; 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide; toluene; acetonitrile;