5'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3'H-spiro[azetidine-3,1'-isobenzofuran]

Base Information

Chemical Name:5'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3'H-spiro[azetidine-3,1'-isobenzofuran]
CAS No.:1398609-72-7
Molecular Formula:C₂₀H₁₄Cl₂F₄N₂O₂
Molecular Weight:461.243
Hs Code.:

Synonyms:5'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3'H-spiro[azetidine-3,1'-isobenzofuran]

Suppliers and Price of 5'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3'H-spiro[azetidine-3,1'-isobenzofuran]

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3'H-spiro[azetidine-3,1'-isobenzofuran]

Chemical Property:

Purity/Quality:: 95%+ or 98%+ ^*data from raw suppliers

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Technology Process of 5'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3'H-spiro[azetidine-3,1'-isobenzofuran]

There total 4 articles about 5'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3'H-spiro[azetidine-3,1'-isobenzofuran] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1398609-71-6
1-benzhydryl-5'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3'H-spiro[azetidine-3,1'-isobenzofuran]

: 1398609-72-7
5'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3'H-spiro[azetidine-3,1'-isobenzofuran]

Guidance literature:: 1-benzhydryl-5'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3'H-spiro[azetidine-3,1'-isobenzofuran]; With carbonochloridic acid 1-chloro-ethyl ester; In acetonitrile; at 75 ℃; for 2h;

With methanol; for 1h; Reflux;

Reference yield:

: 1398609-69-2
1-benzhydryl-5'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3'H-spiro[azetidine-3,1'-isobenzofuran]-3'-one

: 1398609-72-7
5'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3'H-spiro[azetidine-3,1'-isobenzofuran]

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium borohydride / tetrahydrofuran / 16 h / 20 °C

2.1: triethylamine; p-toluenesulfonylanhydride / toluene / 16 h / 0 - 20 °C

3.1: carbonochloridic acid 1-chloro-ethyl ester / acetonitrile / 2 h / 75 °C

3.2: 1 h / Reflux

With lithium borohydride; carbonochloridic acid 1-chloro-ethyl ester; p-toluenesulfonylanhydride; triethylamine; In tetrahydrofuran; toluene; acetonitrile;

Reference yield:

: 1398609-68-1
1-benzhydryl-3-(2-bromo-4-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)phenyl)azetidin-3-ol

: 1398609-72-7
5'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3'H-spiro[azetidine-3,1'-isobenzofuran]

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 12 h / 85 °C

2.1: lithium borohydride / tetrahydrofuran / 16 h / 20 °C

3.1: triethylamine; p-toluenesulfonylanhydride / toluene / 16 h / 0 - 20 °C

4.1: carbonochloridic acid 1-chloro-ethyl ester / acetonitrile / 2 h / 75 °C

4.2: 1 h / Reflux

With lithium borohydride; carbonochloridic acid 1-chloro-ethyl ester; p-toluenesulfonylanhydride; palladium diacetate; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; toluene; acetonitrile;