1-benzhydryl-3-(2-bromo-4-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)phenyl)azetidin-3-ol

Base Information

Chemical Name:1-benzhydryl-3-(2-bromo-4-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)phenyl)azetidin-3-ol
CAS No.:1398609-68-1
Molecular Formula:C₃₂H₂₃BrCl₂F₄N₂O₂
Molecular Weight:694.35
Hs Code.:

Synonyms:1-benzhydryl-3-(2-bromo-4-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)phenyl)azetidin-3-ol

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Chemical Property of 1-benzhydryl-3-(2-bromo-4-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)phenyl)azetidin-3-ol

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Technology Process of 1-benzhydryl-3-(2-bromo-4-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)phenyl)azetidin-3-ol

There total 1 articles about 1-benzhydryl-3-(2-bromo-4-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)phenyl)azetidin-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1398609-68-1
1-benzhydryl-3-(2-bromo-4-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)phenyl)azetidin-3-ol

Guidance literature:: With isopropylmagnesium chloride; In tetrahydrofuran; at 0 - 40 ℃; for 1.5h; Inert atmosphere;

In tetrahydrofuran; at -40 - 20 ℃; for 2.5h;

With ammonium chloride; In tetrahydrofuran; water;

Reference yield: 70.0%

: 201230-82-2
carbon monoxide

: 1398609-68-1
1-benzhydryl-3-(2-bromo-4-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)phenyl)azetidin-3-ol

: 1398609-69-2
1-benzhydryl-5'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3'H-spiro[azetidine-3,1'-isobenzofuran]-3'-one

Guidance literature:: With palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In methanol; under 760.051 Torr;
DOI:10.1016/j.bmcl.2016.02.027

Reference yield:

: 1398609-68-1
1-benzhydryl-3-(2-bromo-4-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)phenyl)azetidin-3-ol

: 1398609-71-6
1-benzhydryl-5'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3'H-spiro[azetidine-3,1'-isobenzofuran]

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 12 h / 85 °C

2: lithium borohydride / tetrahydrofuran / 16 h / 20 °C

3: triethylamine; p-toluenesulfonylanhydride / toluene / 16 h / 0 - 20 °C

With lithium borohydride; p-toluenesulfonylanhydride; palladium diacetate; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; toluene;