1-<(S)-1-(t-butoxycarbonyl)ethyl>-(3S,4R)-3-phenoxy-4-phenylazetidin-2-one

Base Information

Chemical Name:1-<(S)-1-(t-butoxycarbonyl)ethyl>-(3S,4R)-3-phenoxy-4-phenylazetidin-2-one
CAS No.:102108-70-3
Molecular Formula:C₂₂H₂₅NO₄
Molecular Weight:367.445
Hs Code.:

Synonyms:1-<(S)-1-(t-butoxycarbonyl)ethyl>-(3S,4R)-3-phenoxy-4-phenylazetidin-2-one

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Chemical Property of 1-<(S)-1-(t-butoxycarbonyl)ethyl>-(3S,4R)-3-phenoxy-4-phenylazetidin-2-one

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Technology Process of 1-<(S)-1-(t-butoxycarbonyl)ethyl>-(3S,4R)-3-phenoxy-4-phenylazetidin-2-one

There total 1 articles about 1-<(S)-1-(t-butoxycarbonyl)ethyl>-(3S,4R)-3-phenoxy-4-phenylazetidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.1%

: 78688-64-9
(S)-N-benzylidene-1-t-butoxycarbonylethylamine

: 701-99-5
Phenoxyacetyl chloride

: 102108-70-3
1-<(S)-1-(t-butoxycarbonyl)ethyl>-(3S,4R)-3-phenoxy-4-phenylazetidin-2-one

: 102209-06-3
1-<(S)-1-(t-butoxycarbonyl)ethyl>-(3R,4S)-3-phenoxy-4-phenylazetidin-2-one

Guidance literature:: With triethylamine; In dichloromethane; -78 degC, 30 min., allowed to warm to r.t. for 12 h;
DOI:10.1016/S0040-4020(01)86038-5

Reference yield:

: 102108-70-3
1-<(S)-1-(t-butoxycarbonyl)ethyl>-(3S,4R)-3-phenoxy-4-phenylazetidin-2-one

: 120346-42-1
(S)-2-phenoxy-3-phenylpropanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) lithium diisopropylamide / 1.) THF, 0 deg C, 15 min, 2.) THF, -78 deg C, 5 h

2: H₂ / Pd-C

3: 6 N hydrochloric acid / tetrahydrofuran; H₂O / 110 °C

With hydrogenchloride; hydrogen; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; water;
DOI:10.1021/ja00255a063

Reference yield:

: 102108-70-3
1-<(S)-1-(t-butoxycarbonyl)ethyl>-(3S,4R)-3-phenoxy-4-phenylazetidin-2-one

: C₂₂H₂₅⁽²⁾H₂NO₄

Guidance literature:: With deuterium; palladium on activated charcoal; In deuteromethanol; for 24h; Yield given; Ambient temperature;
DOI:10.1021/ja00271a048