(E)-6-(4-phenylcyclohexyl)-2-thioxo-5-(3-trifluoromethylbenzyl)-2,3-dihydro-1H-pyrimidin-4-one

Base Information

Chemical Name:(E)-6-(4-phenylcyclohexyl)-2-thioxo-5-(3-trifluoromethylbenzyl)-2,3-dihydro-1H-pyrimidin-4-one
CAS No.:1400902-36-4
Molecular Formula:C₂₄H₂₃F₃N₂OS
Molecular Weight:444.521
Hs Code.:

Synonyms:(E)-6-(4-phenylcyclohexyl)-2-thioxo-5-(3-trifluoromethylbenzyl)-2,3-dihydro-1H-pyrimidin-4-one

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Chemical Property of (E)-6-(4-phenylcyclohexyl)-2-thioxo-5-(3-trifluoromethylbenzyl)-2,3-dihydro-1H-pyrimidin-4-one

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Technology Process of (E)-6-(4-phenylcyclohexyl)-2-thioxo-5-(3-trifluoromethylbenzyl)-2,3-dihydro-1H-pyrimidin-4-one

There total 5 articles about (E)-6-(4-phenylcyclohexyl)-2-thioxo-5-(3-trifluoromethylbenzyl)-2,3-dihydro-1H-pyrimidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 3-oxo-3-(4-phenylcyclohexyl)-2-(3-trifluoromethylbenzyl)-propionic acid ethyl ester

: 17356-08-0
thiourea

: 1400902-36-4
(E)-6-(4-phenylcyclohexyl)-2-thioxo-5-(3-trifluoromethylbenzyl)-2,3-dihydro-1H-pyrimidin-4-one

Guidance literature:: thiourea; With sodium; In ethanol; for 1h; Inert atmosphere; Reflux;

3-oxo-3-(4-phenylcyclohexyl)-2-(3-trifluoromethylbenzyl)-propionic acid ethyl ester; In ethanol; at 0 ℃; for 1.5h; Reflux;

Reference yield:

: 1466-73-5
trans-4-phenylcyclohexanecarboxylic acid

: 1400902-36-4
(E)-6-(4-phenylcyclohexyl)-2-thioxo-5-(3-trifluoromethylbenzyl)-2,3-dihydro-1H-pyrimidin-4-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: dmap / dichloromethane / 0.17 h / 20 °C / Molecular sieve

1.2: 1.5 h / 20 °C

1.3: 1.5 h / Reflux

2.1: piperidine; acetic acid / toluene / 48 h / Reflux

3.1: hydrogen / palladium 10% on activated carbon / ethanol / 2 h

4.1: sodium / ethanol / 1 h / Inert atmosphere; Reflux

4.2: 1.5 h / 0 °C / Reflux

With piperidine; dmap; hydrogen; sodium; acetic acid; palladium 10% on activated carbon; In ethanol; dichloromethane; toluene;

Reference yield:

: 95233-37-7,49708-81-8,1346600-43-8
(+/-)-trans-4-(4-chlorophenyl)cyclohexane carboxylic acid

: 1400902-36-4
(E)-6-(4-phenylcyclohexyl)-2-thioxo-5-(3-trifluoromethylbenzyl)-2,3-dihydro-1H-pyrimidin-4-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen / palladium 10% on activated carbon / ethanol / 96 h

1.2: 16 h / 20 °C

1.3: 0.25 h

2.1: dmap / dichloromethane / 0.17 h / 20 °C / Molecular sieve

2.2: 1.5 h / 20 °C

2.3: 1.5 h / Reflux

3.1: piperidine; acetic acid / toluene / 48 h / Reflux

4.1: hydrogen / palladium 10% on activated carbon / ethanol / 2 h

5.1: sodium / ethanol / 1 h / Inert atmosphere; Reflux

5.2: 1.5 h / 0 °C / Reflux

With piperidine; dmap; hydrogen; sodium; acetic acid; palladium 10% on activated carbon; In ethanol; dichloromethane; toluene;