((S)-1-{(2S,4S)-2-[4-(5'-chloro-4'-{[4-((S)-2-methylpiperazin-1-yl)piperidine-1-carbonyl]amino}-2'-trifluoromethoxybiphenyl-4-yl)-1H-imidazol-2-yl]-4-methylpyrrolidine-1-carbonyl}-2-methylpropyl)carbamic acid methyl ester

Base Information

Chemical Name:((S)-1-{(2S,4S)-2-[4-(5'-chloro-4'-{[4-((S)-2-methylpiperazin-1-yl)piperidine-1-carbonyl]amino}-2'-trifluoromethoxybiphenyl-4-yl)-1H-imidazol-2-yl]-4-methylpyrrolidine-1-carbonyl}-2-methylpropyl)carbamic acid methyl ester
CAS No.:1477816-25-3
Molecular Formula:C₃₉H₅₀ClF₃N₈O₅
Molecular Weight:803.325
Hs Code.:

((S)-1-{(2S,4S)-2-[4-(5'-chloro-4'-{[4-((S)-2-methylpiperazin-1-yl)piperidine-1-carbonyl]amino}-2'-trifluoromethoxybiphenyl-4-yl)-1H-imidazol-2-yl]-4-methylpyrrolidine-1-carbonyl}-2-methylpropyl)carbamic acid methyl ester

Synonyms:((S)-1-{(2S,4S)-2-[4-(5'-chloro-4'-{[4-((S)-2-methylpiperazin-1-yl)piperidine-1-carbonyl]amino}-2'-trifluoromethoxybiphenyl-4-yl)-1H-imidazol-2-yl]-4-methylpyrrolidine-1-carbonyl}-2-methylpropyl)carbamic acid methyl ester

Suppliers and Price of ((S)-1-{(2S,4S)-2-[4-(5'-chloro-4'-{[4-((S)-2-methylpiperazin-1-yl)piperidine-1-carbonyl]amino}-2'-trifluoromethoxybiphenyl-4-yl)-1H-imidazol-2-yl]-4-methylpyrrolidine-1-carbonyl}-2-methylpropyl)carbamic acid methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of ((S)-1-{(2S,4S)-2-[4-(5'-chloro-4'-{[4-((S)-2-methylpiperazin-1-yl)piperidine-1-carbonyl]amino}-2'-trifluoromethoxybiphenyl-4-yl)-1H-imidazol-2-yl]-4-methylpyrrolidine-1-carbonyl}-2-methylpropyl)carbamic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ((S)-1-{(2S,4S)-2-[4-(5'-chloro-4'-{[4-((S)-2-methylpiperazin-1-yl)piperidine-1-carbonyl]amino}-2'-trifluoromethoxybiphenyl-4-yl)-1H-imidazol-2-yl]-4-methylpyrrolidine-1-carbonyl}-2-methylpropyl)carbamic acid methyl ester

There total 14 articles about ((S)-1-{(2S,4S)-2-[4-(5'-chloro-4'-{[4-((S)-2-methylpiperazin-1-yl)piperidine-1-carbonyl]amino}-2'-trifluoromethoxybiphenyl-4-yl)-1H-imidazol-2-yl]-4-methylpyrrolidine-1-carbonyl}-2-methylpropyl)carbamic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (S)-4-[1-(5-chloro-4'-{2-[(2S,4S)-1-((S)-2-methoxycarbonylamino-3-methylbutyryl)-4-methylpyrrolidin-2-yl]-1H-imidazol-4-yl}-2-trifluoromethoxybiphenyl-4-ylcarbamoyl)piperidin-4-yl]-3-methylpiperazine-1-carboxylic acid tert-butyl ester di(trifluroacetate)

: 1477816-25-3
((S)-1-{(2S,4S)-2-[4-(5'-chloro-4'-{[4-((S)-2-methylpiperazin-1-yl)piperidine-1-carbonyl]amino}-2'-trifluoromethoxybiphenyl-4-yl)-1H-imidazol-2-yl]-4-methylpyrrolidine-1-carbonyl}-2-methylpropyl)carbamic acid methyl ester

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 0.5h; Inert atmosphere;

Reference yield:

: 19099-93-5
benzyl 4-oxo-1-piperidinecarboxylate

: 1477816-25-3
((S)-1-{(2S,4S)-2-[4-(5'-chloro-4'-{[4-((S)-2-methylpiperazin-1-yl)piperidine-1-carbonyl]amino}-2'-trifluoromethoxybiphenyl-4-yl)-1H-imidazol-2-yl]-4-methylpyrrolidine-1-carbonyl}-2-methylpropyl)carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium cyanoborohydride; acetic acid / methanol / 1 h / 20 °C / Inert atmosphere

1.2: 45 °C / Inert atmosphere

2.1: hydrogen; palladium 10% on activated carbon / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

3.1: dichloromethane / 6 h / 20 °C / Inert atmosphere

3.2: Inert atmosphere

4.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; sodium hydrogencarbonate / water; 1,4-dioxane / 60 h / 90 °C / Inert atmosphere

4.2: Inert atmosphere

5.1: hydrogenchloride / 1,4-dioxane / 0.5 h / 20 °C / Inert atmosphere

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; sodium cyanoborohydride; sodium hydrogencarbonate; acetic acid; XPhos; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water;

Reference yield:

: 1477815-62-5
(S)-4-(1-benzyloxycarbonylpiperidin-4-yl)-3-methylpiperazine-1-carboxylic acid tert-butyl ester

: 1477816-25-3
((S)-1-{(2S,4S)-2-[4-(5'-chloro-4'-{[4-((S)-2-methylpiperazin-1-yl)piperidine-1-carbonyl]amino}-2'-trifluoromethoxybiphenyl-4-yl)-1H-imidazol-2-yl]-4-methylpyrrolidine-1-carbonyl}-2-methylpropyl)carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen; palladium 10% on activated carbon / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

2.1: dichloromethane / 6 h / 20 °C / Inert atmosphere

2.2: Inert atmosphere

3.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; sodium hydrogencarbonate / water; 1,4-dioxane / 60 h / 90 °C / Inert atmosphere

3.2: Inert atmosphere

4.1: hydrogenchloride / 1,4-dioxane / 0.5 h / 20 °C / Inert atmosphere

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; sodium hydrogencarbonate; XPhos; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;