(S)-4-[1-(4-bromo-2-chloro-5-trifluoromethoxyphenylcarbamoyl)piperidin-4-yl]-3-methylpiperazinecarboxylic acid tert-butyl ester

Base Information

Chemical Name:(S)-4-[1-(4-bromo-2-chloro-5-trifluoromethoxyphenylcarbamoyl)piperidin-4-yl]-3-methylpiperazinecarboxylic acid tert-butyl ester
CAS No.:1477815-63-6
Molecular Formula:C₂₃H₃₁BrClF₃N₄O₄
Molecular Weight:599.876
Hs Code.:

Synonyms:(S)-4-[1-(4-bromo-2-chloro-5-trifluoromethoxyphenylcarbamoyl)piperidin-4-yl]-3-methylpiperazinecarboxylic acid tert-butyl ester

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Chemical Property of (S)-4-[1-(4-bromo-2-chloro-5-trifluoromethoxyphenylcarbamoyl)piperidin-4-yl]-3-methylpiperazinecarboxylic acid tert-butyl ester

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Technology Process of (S)-4-[1-(4-bromo-2-chloro-5-trifluoromethoxyphenylcarbamoyl)piperidin-4-yl]-3-methylpiperazinecarboxylic acid tert-butyl ester

There total 5 articles about (S)-4-[1-(4-bromo-2-chloro-5-trifluoromethoxyphenylcarbamoyl)piperidin-4-yl]-3-methylpiperazinecarboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

: 115844-00-3
4-bromo-2-chloro-5-(trifluoromethoxy)phenylamine

: 1477815-58-9
(S)-3-methyl-4-(piperidin-4-yl)piperazine-1-carboxylic acid tert-butyl ester

: 530-62-1
1,1'-carbonyldiimidazole

: 1477815-63-6
(S)-4-[1-(4-bromo-2-chloro-5-trifluoromethoxyphenylcarbamoyl)piperidin-4-yl]-3-methylpiperazinecarboxylic acid tert-butyl ester

Guidance literature:: 4-bromo-2-chloro-5-(trifluoromethoxy)phenylamine; 1,1'-carbonyldiimidazole; In dichloromethane; at 20 ℃; for 6h; Inert atmosphere;

(S)-3-methyl-4-(piperidin-4-yl)piperazine-1-carboxylic acid tert-butyl ester; In dichloromethane; Inert atmosphere;

Reference yield:

: 1477815-62-5
(S)-4-(1-benzyloxycarbonylpiperidin-4-yl)-3-methylpiperazine-1-carboxylic acid tert-butyl ester

: 1477815-63-6
(S)-4-[1-(4-bromo-2-chloro-5-trifluoromethoxyphenylcarbamoyl)piperidin-4-yl]-3-methylpiperazinecarboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogen; palladium 10% on activated carbon / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

2.1: dichloromethane / 6 h / 20 °C / Inert atmosphere

2.2: Inert atmosphere

With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; dichloromethane;

Reference yield:

: 19099-93-5
benzyl 4-oxo-1-piperidinecarboxylate

: 1477815-63-6
(S)-4-[1-(4-bromo-2-chloro-5-trifluoromethoxyphenylcarbamoyl)piperidin-4-yl]-3-methylpiperazinecarboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium cyanoborohydride; acetic acid / methanol / 1 h / 20 °C / Inert atmosphere

1.2: 45 °C / Inert atmosphere

2.1: hydrogen; palladium 10% on activated carbon / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

3.1: dichloromethane / 6 h / 20 °C / Inert atmosphere

3.2: Inert atmosphere

With palladium 10% on activated carbon; hydrogen; sodium cyanoborohydride; acetic acid; In tetrahydrofuran; methanol; dichloromethane;