1-{[3-(Benzyloxy)isoxazol-5-yl]carbonyl}-4-(2-tert-butylphenyl)piperazine

Base Information

Chemical Name:1-{[3-(Benzyloxy)isoxazol-5-yl]carbonyl}-4-(2-tert-butylphenyl)piperazine
CAS No.:1252657-73-0
Molecular Formula:C₂₅H₂₉N₃O₃
Molecular Weight:419.524
Hs Code.:

Synonyms:1-{[3-(Benzyloxy)isoxazol-5-yl]carbonyl}-4-(2-tert-butylphenyl)piperazine

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Chemical Property of 1-{[3-(Benzyloxy)isoxazol-5-yl]carbonyl}-4-(2-tert-butylphenyl)piperazine

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Technology Process of 1-{[3-(Benzyloxy)isoxazol-5-yl]carbonyl}-4-(2-tert-butylphenyl)piperazine

There total 3 articles about 1-{[3-(Benzyloxy)isoxazol-5-yl]carbonyl}-4-(2-tert-butylphenyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1-(2-tert-butylphenyl)piperazine dihydrochloride

: 2552-54-7
3-(benzyloxy)isoxazole-5-carboxylic acid

: 1252657-73-0
1-{[3-(Benzyloxy)isoxazol-5-yl]carbonyl}-4-(2-tert-butylphenyl)piperazine

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield:

: 100-39-0
benzyl bromide

: 1252657-73-0
1-{[3-(Benzyloxy)isoxazol-5-yl]carbonyl}-4-(2-tert-butylphenyl)piperazine

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 50 °C

2: water; lithium hydroxide monohydrate / tetrahydrofuran / 4 h / 40 °C

3: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 16 h / 20 °C

With lithium hydroxide monohydrate; water; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 205115-22-6
3-benzyloxyisoxazole-5-carboxylic acid methyl ester

: 1252657-73-0
1-{[3-(Benzyloxy)isoxazol-5-yl]carbonyl}-4-(2-tert-butylphenyl)piperazine

Guidance literature:: Multi-step reaction with 2 steps

1: water; lithium hydroxide monohydrate / tetrahydrofuran / 4 h / 40 °C

2: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 16 h / 20 °C

With lithium hydroxide monohydrate; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;