3-(2-Chloroethyl)-2-methyl-9-hydroxy--6, 7,8,9-tetrahydro-4H-pyrido [1,2-a] pyrimidin-4-one Hcl

Base Information

• Chemical Name: 3-(2-Chloroethyl)-2-methyl-9-hydroxy--6, 7,8,9-tetrahydro-4H-pyrido [1,2-a] pyrimidin-4-one Hcl
• CAS No.: 849727-63-5
• Molecular Formula: C11H15 Cl N2 O2 . Cl H
• Molecular Weight: 279.166
• Mol file: 849727-63-5.mol

Synonyms:4H-Pyrido[1,2-a]pyrimidin-4-one,3-(2-chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-, monohydrochloride(9CI);3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-onehydrochloride

Chemical Property of 3-(2-Chloroethyl)-2-methyl-9-hydroxy--6, 7,8,9-tetrahydro-4H-pyrido [1,2-a] pyrimidin-4-one Hcl

Chemical Property:

• PSA: 55.12000
• LogP: 1.96220

Purity/Quality:

99% ^*data from raw suppliers

3-(2-Chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-onehydrochloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(2-Chloroethyl)-2-methyl-9-hydroxy--6, 7,8,9-tetrahydro-4H-pyrido [1,2-a] pyrimidin-4-one Hcl

There total 7 articles about 3-(2-Chloroethyl)-2-methyl-9-hydroxy--6, 7,8,9-tetrahydro-4H-pyrido [1,2-a] pyrimidin-4-one Hcl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

9-(benzyloxy)-3-(2-chloroethyl)-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one (147687-17-0) → (±)-3-(2-chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one monohydrochloride (849727-63-5)

Guidance literature:

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; In methanol;

DOI:10.2174/1570178611666140219004433

Reference yield: 69.0%

3-(2-chloroethyl)-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one monohydrochloride (849727-62-4) → (±)-3-(2-chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one monohydrochloride (849727-63-5)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; pyrographite; In methanol; at 50 ℃; under 112.511 Torr; Reagent/catalyst; Solvent; Time;

DOI:10.1021/op049782x

Reference yield: 46.0%

3-(2-chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one (130049-82-0) → (±)-3-(2-chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one monohydrochloride (849727-63-5)

Guidance literature:

With hydrogenchloride; In water; butanone; pH=2;

upstream raw materials:

3-(2-chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one

3-(2-chloroethyl)-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one monohydrochloride

3-acetyl-2-oxo-4,5-dihydrofuran

2-amino-3-benzyloxypyridine

Downstream raw materials:

paliperidone

(+)-9-hydroxyrisperidone

(+)-Paliperidone

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