3-(2-chloroethyl)-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one hydrochloride

Base Information

Chemical Name:3-(2-chloroethyl)-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one hydrochloride
CAS No.:849727-62-4
Molecular Formula:C11H12Cl2N2O2
Molecular Weight:275.134
Hs Code.:
Mol file:849727-62-4.mol

Synonyms:Paliperidone Tetradehydro Chloroethyl Impurity;3-(2-chloroethyl)-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one hydrochloride

Suppliers and Price of 3-(2-chloroethyl)-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
3-(2-Chloroethyl)-9-hydroxy-2-methyl-4H-Pyrido[1,2-a]pyrimidin-4-oneHydrochloride
25mg
$ 215.00

Medical Isotopes, Inc.
3-(2-Chloroethyl)-9-hydroxy-2-methyl-4H-Pyrido[1,2-α]pyrimidin-4-oneHCl
250 mg
$ 2400.00

Medical Isotopes, Inc.
3-(2-Chloroethyl)-9-hydroxy-2-methyl-4H-Pyrido[1,2-α]pyrimidin-4-oneHCl
25 mg
$ 675.00

Total 18 raw suppliers

Chemical Property of 3-(2-chloroethyl)-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one hydrochloride

Chemical Property:

Vapor Pressure:0-0Pa at 20-25℃
PSA：54.60000
Density:1.6g/cm3 at 20℃
LogP:2.29180
Storage Temp.:Refrigerator
Solubility.:DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99.9% ^*data from raw suppliers

3-(2-Chloroethyl)-9-hydroxy-2-methyl-4H-Pyrido[1,2-a]pyrimidin-4-oneHydrochloride ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses 3-(2-Chloroethyl)-9-hydroxy-2-methyl-4H-Pyrido[1,2-a]pyrimidin-4-one Hydrochloride is an intermediate in the synthesis of analog of Paliperidone (P141000), a combined serotonin and dopamine receptor antagonist.

Technology Process of 3-(2-chloroethyl)-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one hydrochloride

There total 7 articles about 3-(2-chloroethyl)-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.82%

: 147687-17-0
9-(benzyloxy)-3-(2-chloroethyl)-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one

: 849727-62-4
3-(2-chloroethyl)-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one monohydrochloride

Guidance literature:: 9-(benzyloxy)-3-(2-chloroethyl)-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one; With hydrogenchloride; In water; at 25 - 75 ℃; for 2.5h;

In water; acetone; at 5 - 30 ℃; for 1h;

Reference yield: 76.0%

: 16867-03-1
2-amino-3-hydroxypyridine

: 517-23-7,594837-91-9,98634-97-0,313643-49-1
3-acetyl-2-oxo-4,5-dihydrofuran

: 849727-62-4
3-(2-chloroethyl)-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one monohydrochloride

Guidance literature:: 2-amino-3-hydroxypyridine; 3-acetyl-2-oxo-4,5-dihydrofuran; With trichlorophosphate; In toluene; at 30 - 40 ℃; for 24h; Large scale;

With hydrogenchloride; In isopropyl alcohol; at 0 - 5 ℃; Large scale;
DOI:10.1080/00304948.2016.1165060