tert-butyl (4R,5S,R_S)-2,2-dimethyl-4-{2-[(4-methylphenyl)sulfinyl]-2-propenyl}-1,3-dioxan-5-ylcarbamate

Base Information

• Chemical Name: tert-butyl (4R,5S,R_S)-2,2-dimethyl-4-{2-[(4-methylphenyl)sulfinyl]-2-propenyl}-1,3-dioxan-5-ylcarbamate
• CAS No.: 505085-61-0
• Molecular Formula: C₂₁H₃₁NO₅S
• Molecular Weight: 409.547

Synonyms:tert-butyl (4R,5S,R_S)-2,2-dimethyl-4-{2-[(4-methylphenyl)sulfinyl]-2-propenyl}-1,3-dioxan-5-ylcarbamate

Chemical Property of tert-butyl (4R,5S,R_S)-2,2-dimethyl-4-{2-[(4-methylphenyl)sulfinyl]-2-propenyl}-1,3-dioxan-5-ylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl (4R,5S,R_S)-2,2-dimethyl-4-{2-[(4-methylphenyl)sulfinyl]-2-propenyl}-1,3-dioxan-5-ylcarbamate

There total 2 articles about tert-butyl (4R,5S,R_S)-2,2-dimethyl-4-{2-[(4-methylphenyl)sulfinyl]-2-propenyl}-1,3-dioxan-5-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2,2-dimethoxy-propane (77-76-9) + tert-butyl (1'S,2'R,RS)-2-hydroxy-1-(hydroxymethyl)-4-[(4-methylphenyl)sulfinyl]pent-4-enylcarbamate (505085-60-9) → tert-butyl (4R,5S,RS)-2,2-dimethyl-4-{2-[(4-methylphenyl)sulfinyl]-2-propenyl}-1,3-dioxan-5-ylcarbamate (505085-61-0)

Guidance literature:

With toluene-4-sulfonic acid; In acetone; at 20 ℃; for 0.5h;

DOI:10.1002/1099-0690(200301)2003:1<217::AID-EJOC217>3.0.CO;2-W

Reference yield:

(S)-4-[(R)-1-Hydroxy-3-((R)-toluene-4-sulfinyl)-but-3-enyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester (399559-48-9) → tert-butyl (4R,5S,RS)-2,2-dimethyl-4-{2-[(4-methylphenyl)sulfinyl]-2-propenyl}-1,3-dioxan-5-ylcarbamate (505085-61-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / pTsOH / methanol / 3 h / 20 °C

2: 90 percent / pTsOH / acetone / 0.5 h / 20 °C

With toluene-4-sulfonic acid; In methanol; acetone;

DOI:10.1002/1099-0690(200301)2003:1<217::AID-EJOC217>3.0.CO;2-W

Reference yield: 93.0%

tert-butyl (4R,5S,RS)-2,2-dimethyl-4-{2-[(4-methylphenyl)sulfinyl]-2-propenyl}-1,3-dioxan-5-ylcarbamate (505085-61-0) → tert-butyl (4aS,7RS,8aR,RS)-2,2-dimethyl-7-[(4-methylphenyl)sulfinyl]hexahydro-5H-[1,3]dioxino[5,4-b]pyridine-5-carboxylate

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

DOI:10.1002/1099-0690(200301)2003:1<217::AID-EJOC217>3.0.CO;2-W

upstream raw materials:

2,2-dimethoxy-propane

tert-butyl (1'S,2'R,R_S)-2-hydroxy-1-(hydroxymethyl)-4-[(4-methylphenyl)sulfinyl]pent-4-enylcarbamate

(S)-4-[(R)-1-Hydroxy-3-((R)-toluene-4-sulfinyl)-but-3-enyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 505085-61-0 tert-butyl (4R,5S,R_S)-2,2-dimethyl-4-{2-[(4-methylphenyl)sulfinyl]-2-propenyl}-1,3-dioxan-5-ylcarbamate

Send

Send

Metric Ton KG G Pound L ML

Send

Send