N-[4-[(4,5-dichloro-2-fluorophenyl)amino]quinazolin-6-yl]-2-hydrazinylacetamide

Base Information

Chemical Name:N-[4-[(4,5-dichloro-2-fluorophenyl)amino]quinazolin-6-yl]-2-hydrazinylacetamide
CAS No.:1400741-90-3
Molecular Formula:C₁₆H₁₃Cl₂FN₆O
Molecular Weight:395.223
Hs Code.:

Synonyms:N-[4-[(4,5-dichloro-2-fluorophenyl)amino]quinazolin-6-yl]-2-hydrazinylacetamide

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Chemical Property of N-[4-[(4,5-dichloro-2-fluorophenyl)amino]quinazolin-6-yl]-2-hydrazinylacetamide

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Technology Process of N-[4-[(4,5-dichloro-2-fluorophenyl)amino]quinazolin-6-yl]-2-hydrazinylacetamide

There total 5 articles about N-[4-[(4,5-dichloro-2-fluorophenyl)amino]quinazolin-6-yl]-2-hydrazinylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 733009-42-2
TKS 050

: 1400741-90-3
N-[4-[(4,5-dichloro-2-fluorophenyl)amino]quinazolin-6-yl]-2-hydrazinylacetamide

Guidance literature:: With hydrazine hydrate; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 455922-78-8
4-[(3,4-dichloro-6-fluorophenyl)amino]-6-nitroquinazoline

: 1400741-90-3
N-[4-[(4,5-dichloro-2-fluorophenyl)amino]quinazolin-6-yl]-2-hydrazinylacetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid; iron / water / 1.5 h / 100 °C / Inert atmosphere

1.2: 10 °C / pH 8 - 9

2.1: tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

2.2: pH 8

3.1: hydrazine hydrate / tetrahydrofuran / 20 °C

With iron; hydrazine hydrate; acetic acid; In tetrahydrofuran; water;

Reference yield:

: 455922-81-3
6-amino-4-(4,5-dichloro-2-fluorophenylamino)quinazoline

: 1400741-90-3
N-[4-[(4,5-dichloro-2-fluorophenyl)amino]quinazolin-6-yl]-2-hydrazinylacetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

1.2: pH 8

2.1: hydrazine hydrate / tetrahydrofuran / 20 °C

With hydrazine hydrate; In tetrahydrofuran;