4-diethylphophonyl-1-p-methoxybenzyl-2-thiomethyl-5-imidazolylcarboxylic acid

Base Information

Chemical Name:4-diethylphophonyl-1-p-methoxybenzyl-2-thiomethyl-5-imidazolylcarboxylic acid
CAS No.:161124-27-2
Molecular Formula:C₁₇H₂₃N₂O₆PS
Molecular Weight:414.419
Hs Code.:

Synonyms:4-diethylphophonyl-1-p-methoxybenzyl-2-thiomethyl-5-imidazolylcarboxylic acid

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Chemical Property of 4-diethylphophonyl-1-p-methoxybenzyl-2-thiomethyl-5-imidazolylcarboxylic acid

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Technology Process of 4-diethylphophonyl-1-p-methoxybenzyl-2-thiomethyl-5-imidazolylcarboxylic acid

There total 4 articles about 4-diethylphophonyl-1-p-methoxybenzyl-2-thiomethyl-5-imidazolylcarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 161124-26-1
methyl 4-diethylphosphonyl-1-p-methoxybenzyl-2-thiomethyl-5-imidazolylcarboxylate

: 161124-27-2
4-diethylphophonyl-1-p-methoxybenzyl-2-thiomethyl-5-imidazolylcarboxylic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; for 3h; Ambient temperature;
DOI:10.1002/jhet.5570310672

Reference yield:

: methyl 2-mercapto-1-p-methoxybenzyl-5-imidazolylcarboxylate

: 161124-27-2
4-diethylphophonyl-1-p-methoxybenzyl-2-thiomethyl-5-imidazolylcarboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 75 percent / K₂CO₃ / methanol / 1.5 h / 0 °C

2: 44 percent / N-bromosuccinimide, 2,2'-azobis(2-methyl-propionitrile) / CHCl₃; CCl₄ / 20 h / Heating

3: 62 percent / Et₃N, tetrakis(triphenylphosphine)palladium / toluene / 8 h / 90 °C

4: 82 percent / LiOH / tetrahydrofuran / 3 h / Ambient temperature

With lithium hydroxide; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2,2'-azobis(isobutyronitrile); potassium carbonate; triethylamine; In tetrahydrofuran; methanol; tetrachloromethane; chloroform; toluene;
DOI:10.1002/jhet.5570310672

Reference yield:

: 161124-24-9
methyl 1-p-methoxybenzyl-2-thiomethyl-5-imidazolylcarboxylate

: 161124-27-2
4-diethylphophonyl-1-p-methoxybenzyl-2-thiomethyl-5-imidazolylcarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 44 percent / N-bromosuccinimide, 2,2'-azobis(2-methyl-propionitrile) / CHCl₃; CCl₄ / 20 h / Heating

2: 62 percent / Et₃N, tetrakis(triphenylphosphine)palladium / toluene / 8 h / 90 °C

3: 82 percent / LiOH / tetrahydrofuran / 3 h / Ambient temperature

With lithium hydroxide; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2,2'-azobis(isobutyronitrile); triethylamine; In tetrahydrofuran; tetrachloromethane; chloroform; toluene;
DOI:10.1002/jhet.5570310672