methyl 4-diethylphosphonyl-1-p-methoxybenzyl-2-thiomethyl-5-imidazolylcarboxylate

Base Information

Chemical Name:methyl 4-diethylphosphonyl-1-p-methoxybenzyl-2-thiomethyl-5-imidazolylcarboxylate
CAS No.:161124-26-1
Molecular Formula:C₁₈H₂₅N₂O₆PS
Molecular Weight:428.446
Hs Code.:

Synonyms:methyl 4-diethylphosphonyl-1-p-methoxybenzyl-2-thiomethyl-5-imidazolylcarboxylate

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Chemical Property of methyl 4-diethylphosphonyl-1-p-methoxybenzyl-2-thiomethyl-5-imidazolylcarboxylate

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Technology Process of methyl 4-diethylphosphonyl-1-p-methoxybenzyl-2-thiomethyl-5-imidazolylcarboxylate

There total 3 articles about methyl 4-diethylphosphonyl-1-p-methoxybenzyl-2-thiomethyl-5-imidazolylcarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 762-04-9
phosphonic acid diethyl ester

: 161124-25-0
methyl 4-bromo-1-p-methoxybenzyl-2-thiomethyl-5-imidazolylcarboxylate

: 161124-26-1
methyl 4-diethylphosphonyl-1-p-methoxybenzyl-2-thiomethyl-5-imidazolylcarboxylate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; In toluene; at 90 ℃; for 8h;
DOI:10.1002/jhet.5570310672

Reference yield:

: methyl 2-mercapto-1-p-methoxybenzyl-5-imidazolylcarboxylate

: 161124-26-1
methyl 4-diethylphosphonyl-1-p-methoxybenzyl-2-thiomethyl-5-imidazolylcarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 75 percent / K₂CO₃ / methanol / 1.5 h / 0 °C

2: 44 percent / N-bromosuccinimide, 2,2'-azobis(2-methyl-propionitrile) / CHCl₃; CCl₄ / 20 h / Heating

3: 62 percent / Et₃N, tetrakis(triphenylphosphine)palladium / toluene / 8 h / 90 °C

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2,2'-azobis(isobutyronitrile); potassium carbonate; triethylamine; In methanol; tetrachloromethane; chloroform; toluene;
DOI:10.1002/jhet.5570310672

Reference yield:

: 161124-24-9
methyl 1-p-methoxybenzyl-2-thiomethyl-5-imidazolylcarboxylate

: 161124-26-1
methyl 4-diethylphosphonyl-1-p-methoxybenzyl-2-thiomethyl-5-imidazolylcarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 44 percent / N-bromosuccinimide, 2,2'-azobis(2-methyl-propionitrile) / CHCl₃; CCl₄ / 20 h / Heating

2: 62 percent / Et₃N, tetrakis(triphenylphosphine)palladium / toluene / 8 h / 90 °C

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2,2'-azobis(isobutyronitrile); triethylamine; In tetrachloromethane; chloroform; toluene;
DOI:10.1002/jhet.5570310672