diethyl 5-amino-1-p-methoxybenzyl-2-thiomethyl-4-imidazolylphosphonate

Base Information

Chemical Name:diethyl 5-amino-1-p-methoxybenzyl-2-thiomethyl-4-imidazolylphosphonate
CAS No.:161124-28-3
Molecular Formula:C₁₆H₂₄N₃O₄PS
Molecular Weight:385.424
Hs Code.:

Synonyms:diethyl 5-amino-1-p-methoxybenzyl-2-thiomethyl-4-imidazolylphosphonate

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Chemical Property of diethyl 5-amino-1-p-methoxybenzyl-2-thiomethyl-4-imidazolylphosphonate

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Technology Process of diethyl 5-amino-1-p-methoxybenzyl-2-thiomethyl-4-imidazolylphosphonate

There total 6 articles about diethyl 5-amino-1-p-methoxybenzyl-2-thiomethyl-4-imidazolylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 161124-27-2
4-diethylphophonyl-1-p-methoxybenzyl-2-thiomethyl-5-imidazolylcarboxylic acid

: 75-65-0
tert-butyl alcohol

: 161124-28-3
diethyl 5-amino-1-p-methoxybenzyl-2-thiomethyl-4-imidazolylphosphonate

: diethyl 5-tert-butoxycarbonylamino-1-p-methoxybenzyl-2-thiomethyl-4-imidazolylphosphonate

Guidance literature:: With diphenylphosphoranyl azide; triethylamine; for 24h; Heating;
DOI:10.1002/jhet.5570310672

Reference yield: 8.0%

: 161124-27-2
4-diethylphophonyl-1-p-methoxybenzyl-2-thiomethyl-5-imidazolylcarboxylic acid

: 161124-28-3
diethyl 5-amino-1-p-methoxybenzyl-2-thiomethyl-4-imidazolylphosphonate

: diethyl 5-tert-butoxycarbonylamino-1-p-methoxybenzyl-2-thiomethyl-4-imidazolylphosphonate

Guidance literature:: With diphenylphosphoranyl azide; triethylamine; tert-butyl alcohol; for 24h; Heating;
DOI:10.1002/jhet.5570310672

Reference yield:

: methyl 2-mercapto-1-p-methoxybenzyl-5-imidazolylcarboxylate

: 161124-28-3
diethyl 5-amino-1-p-methoxybenzyl-2-thiomethyl-4-imidazolylphosphonate

Guidance literature:: Multi-step reaction with 5 steps

1: 75 percent / K₂CO₃ / methanol / 1.5 h / 0 °C

2: 44 percent / N-bromosuccinimide, 2,2'-azobis(2-methyl-propionitrile) / CHCl₃; CCl₄ / 20 h / Heating

3: 62 percent / Et₃N, tetrakis(triphenylphosphine)palladium / toluene / 8 h / 90 °C

4: 82 percent / LiOH / tetrahydrofuran / 3 h / Ambient temperature

5: 65 percent / diphenylphosphoryl azide, Et₃N, t-butyl alcohol / 24 h / Heating

With lithium hydroxide; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2,2'-azobis(isobutyronitrile); diphenylphosphoranyl azide; potassium carbonate; triethylamine; tert-butyl alcohol; In tetrahydrofuran; methanol; tetrachloromethane; chloroform; toluene;
DOI:10.1002/jhet.5570310672