2-PIPERAZINE-4-AMINO-6,7-DIMETHOXY QUINOLINE HYDROCHLORIDE

Base Information

• Chemical Name: 2-PIPERAZINE-4-AMINO-6,7-DIMETHOXY QUINOLINE HYDROCHLORIDE
• CAS No.: 84050-22-6
• Molecular Formula: C14H19N5O2^.HCl
• Molecular Weight: 325.798
• Hs Code.: 2933990090
• Mol file: 84050-22-6.mol

Synonyms:4-Quinazolinamine,6,7-dimethoxy-2-(1-piperazinyl)-, monohydrochloride (9CI);2-Piperazine-4-amino-6,7-dimethoxy quinoline hydrochloride;

Chemical Property of 2-PIPERAZINE-4-AMINO-6,7-DIMETHOXY QUINOLINE HYDROCHLORIDE

Chemical Property:

• Vapor Pressure: 2.92E-12mmHg at 25°C
• Boiling Point: 546.1 °C at 760 mmHg
• Flash Point: 284.1 °C
• PSA: 58.65000
• LogP: 2.62580

Purity/Quality:

99.0% Min ^*data from raw suppliers

2-PIPERAZINE-4-AMINO-6,7-DIMETHOXY QUINAOLINE HYDROCHLORIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-PIPERAZINE-4-AMINO-6,7-DIMETHOXY QUINOLINE HYDROCHLORIDE

There total 2 articles about 2-PIPERAZINE-4-AMINO-6,7-DIMETHOXY QUINOLINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloro-6,7-dimethoxyquinazolin-4-amine (23680-84-4) → 2-piperazinyl-4-amino-6,7-dimethoxyquinazoline hydrochloride (84050-22-6,70843-11-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 33.4 g / 3-methyl-butan-1-ol / 1 h / Heating

2: 10percent aq. HCl / 1.5 h / Heating

With hydrogenchloride; In i-Amyl alcohol;

DOI:10.1021/jm00357a016

Reference yield:

4-amino-6,7-dimethoxy-2-(4-formylpiperazino)quinazoline hydrochloride (84050-21-5) → 2-piperazinyl-4-amino-6,7-dimethoxyquinazoline hydrochloride (84050-22-6,70843-11-7)

Guidance literature:

With hydrogenchloride; for 1.5h; Heating;

DOI:10.1021/jm00357a016

Reference yield:

(E)-4-ethoxycinnamic acid (2373-79-7) + chloroformic acid ethyl ester (541-41-3) + 2-piperazinyl-4-amino-6,7-dimethoxyquinazoline hydrochloride (84050-22-6,70843-11-7) → 2-[4-(4-ethoxycinnamoyl)-piperazin-1-yl]-4-amino-6,7-dimethoxyquinazoline

Guidance literature:

With triethylamine; In acetone;

upstream raw materials:

4-amino-6,7-dimethoxy-2-(4-formylpiperazino)quinazoline hydrochloride

2-chloro-6,7-dimethoxyquinazolin-4-amine

Downstream raw materials:

1-(4-amino-6,7-dimethoxy-quinazolin-2-yl)-4-(3-furan-3-yl-acryloyl)-piperazine

1-(4-amino-6,7-dimethoxy-quinazolin-2-yl)-4-(3-m-tolyl-acryloyl)-piperazine

1-(4-amino-6,7-dimethoxy-quinazolin-2-yl)-4-[3-(4-methoxy-phenyl)-acryloyl]-piperazine

4-amino-2-<4-(4-ethoxycinnamoyl)piperazino>-6,7-dimethoxyquinazoline

Refernces