3,5-difluoro-2-hydrxyphenyl methyl sulfide

Base Information

• Chemical Name: 3,5-difluoro-2-hydrxyphenyl methyl sulfide
• CAS No.: 210350-67-7
• Molecular Formula: C₇H₆F₂OS
• Molecular Weight: 176.187
• Mol file: 210350-67-7.mol

Synonyms:3,5-difluoro-2-hydrxyphenyl methyl sulfide

Chemical Property of 3,5-difluoro-2-hydrxyphenyl methyl sulfide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,5-difluoro-2-hydrxyphenyl methyl sulfide

There total 5 articles about 3,5-difluoro-2-hydrxyphenyl methyl sulfide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

3,5-difluoro-2-(methoxymethyleneoxy)phenyl methyl sulfide (210350-66-6) → 3,5-difluoro-2-hydrxyphenyl methyl sulfide (210350-67-7)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; at 60 ℃; for 4h;

DOI:10.1021/jm980303s

Reference yield:

2,4-difluorophenol (367-27-1) → 3,5-difluoro-2-hydrxyphenyl methyl sulfide (210350-67-7)

Guidance literature:

Multi-step reaction with 5 steps

1: 56 percent / pyridine, KOH / 3.5 h / Heating

2: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 2 h, 2.) THF, hexane, RT, 24 h

3: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 2 h, 2.) THF, hexane, RT, 24 h

4: 71 percent / Bu₄NF, CF₃CH₂OH / tetrahydrofuran / 1.) -78 deg C, 20 min, 2.) RT, 30 min

5: 53 percent / aq. HCl / tetrahydrofuran / 4 h / 60 °C

With pyridine; hydrogenchloride; potassium hydroxide; n-butyllithium; 2,2,2-trifluoroethanol; tetrabutyl ammonium fluoride; In tetrahydrofuran;

DOI:10.1021/jm980303s

Reference yield:

1,3-difluoro-4-(methoxymethoxy)benzene (210350-62-2) → 3,5-difluoro-2-hydrxyphenyl methyl sulfide (210350-67-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 2 h, 2.) THF, hexane, RT, 24 h

2: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 2 h, 2.) THF, hexane, RT, 24 h

3: 71 percent / Bu₄NF, CF₃CH₂OH / tetrahydrofuran / 1.) -78 deg C, 20 min, 2.) RT, 30 min

4: 53 percent / aq. HCl / tetrahydrofuran / 4 h / 60 °C

With hydrogenchloride; n-butyllithium; 2,2,2-trifluoroethanol; tetrabutyl ammonium fluoride; In tetrahydrofuran;

DOI:10.1021/jm980303s

upstream raw materials:

3,5-difluoro-2-(methoxymethyleneoxy)phenyl methyl sulfide

2,4-difluorophenol

1,3-difluoro-4-(methoxymethoxy)benzene

2,4-difluoro-3-(trimethylsilyl)-1-(methoxymethyl)phenol