[2,6-Difluoro-3-(methoxymethoxy)phenyl]-trimethylsilane

Base Information

• Chemical Name: [2,6-Difluoro-3-(methoxymethoxy)phenyl]-trimethylsilane
• CAS No.: 210350-63-3
• Molecular Formula: C₁₁H₁₆F₂O₂Si
• Molecular Weight: 246.329
• DSSTox Substance ID: DTXSID701195756
• Mol file: 210350-63-3.mol

Synonyms:210350-63-3;DTXSID701195756;1,3-Difluoro-4-(methoxymethoxy)-2-(trimethylsilyl)benzene

Chemical Property of [2,6-Difluoro-3-(methoxymethoxy)phenyl]-trimethylsilane

Chemical Property:

• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 246.08876261
• Heavy Atom Count: 16
• Complexity: 221

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COCOC1=C(C(=C(C=C1)F)[Si](C)(C)C)F

Technology Process of [2,6-Difluoro-3-(methoxymethoxy)phenyl]-trimethylsilane

There total 2 articles about [2,6-Difluoro-3-(methoxymethoxy)phenyl]-trimethylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4-difluorophenol (367-27-1) → 2,4-difluoro-3-(trimethylsilyl)-1-(methoxymethyl)phenol (210350-63-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 56 percent / pyridine, KOH / 3.5 h / Heating

2: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 2 h, 2.) THF, hexane, RT, 24 h

With pyridine; potassium hydroxide; n-butyllithium;

DOI:10.1021/jm980303s

Reference yield:

chloro-trimethyl-silane (75-77-4) + 1,3-difluoro-4-(methoxymethoxy)benzene (210350-62-2) → 2,4-difluoro-3-(trimethylsilyl)-1-(methoxymethyl)phenol (210350-63-3)

Guidance literature:

With n-butyllithium; Yield given; Multistep reaction; 1.) THF, hexane, -78 deg C, 2 h, 2.) THF, hexane, RT, 24 h;

DOI:10.1021/jm980303s

Reference yield:

2,4-difluoro-3-(trimethylsilyl)-1-(methoxymethyl)phenol (210350-63-3) → 3,5-difluoro-2-(methoxymethyleneoxy)phenyl methyl sulfide (210350-66-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 2 h, 2.) THF, hexane, RT, 24 h

2: 71 percent / Bu₄NF, CF₃CH₂OH / tetrahydrofuran / 1.) -78 deg C, 20 min, 2.) RT, 30 min

With n-butyllithium; 2,2,2-trifluoroethanol; tetrabutyl ammonium fluoride; In tetrahydrofuran;

DOI:10.1021/jm980303s

upstream raw materials:

chloro-trimethyl-silane

1,3-difluoro-4-(methoxymethoxy)benzene

2,4-difluorophenol

Downstream raw materials:

3,5-difluoro-2-(methoxymethyleneoxy)-4-(trimethylsilyl)phenyl methyl sulfide

3,5-difluoro-2-hydrxyphenyl methyl sulfide

3,5-difluoro-2-(methoxymethyleneoxy)phenyl methyl sulfide