6-(3-nitrophenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine

Base Information

• Chemical Name: 6-(3-nitrophenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
• CAS No.: 68468-97-3
• Molecular Formula: C₁₀H₇N₅O₂S
• Molecular Weight: 261.264
• Mol file: 68468-97-3.mol

Synonyms:6-(3-nitrophenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine

Chemical Property of 6-(3-nitrophenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-(3-nitrophenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine

There total 3 articles about 6-(3-nitrophenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-hydrazinyl-5-(3-nitrophenyl)-6H-1,3,4-thiadiazine monohydrobromide + trimethyl orthoformate (149-73-5) → 6-(3-nitrophenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine (68468-97-3)

Guidance literature:

With trifluoroacetic acid; at 20 ℃; for 12h; Time;

DOI:10.1007/s10593-018-2325-8

Reference yield:

3'-nitro-2-bromoacetophenone (2227-64-7) → 6-(3-nitrophenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine (68468-97-3)

Guidance literature:

Multi-step reaction with 2 steps

1: dimethyl sulfoxide / 1 h / 20 °C

2: trifluoroacetic acid / 12 h / 20 °C

With trifluoroacetic acid; In dimethyl sulfoxide;

DOI:10.1007/s10593-018-2325-8

Reference yield:

4-amino-3-mercapto-1,2,4-triazole (4343-75-3) → 6-(3-nitrophenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine (68468-97-3)

Guidance literature:

In ethanol;

upstream raw materials:

4-amino-3-mercapto-1,2,4-triazole

3'-nitro-2-bromoacetophenone

trimethyl orthoformate