C₃₂H₃₀N₂O₈

Base Information

• Chemical Name: C₃₂H₃₀N₂O₈
• CAS No.: 851121-92-1
• Molecular Formula: C₃₂H₃₀N₂O₈
• Molecular Weight: 570.599
• Mol file: 851121-92-1.mol

Synonyms:C₃₂H₃₀N₂O₈

Chemical Property of C₃₂H₃₀N₂O₈

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₂H₃₀N₂O₈

There total 33 articles about C₃₂H₃₀N₂O₈ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-hydroxymethyl-3-iodo-6-methoxy-5-methyl-phenol (351379-10-7) → C32H30N2O8 (851121-92-1)

Guidance literature:

Multi-step reaction with 15 steps

1.1: 85 percent / K₂CO₃ / acetone / 4 h / Heating

2.1: sodium hydride / tetrahydrofuran; dimethylformamide / 0.17 h / 0 °C

2.2: 99 percent / TBAI / tetrahydrofuran; dimethylformamide / 12 h / 20 °C

3.1: 87 percent / TEA; TBABr; (o-tolyl)3P / Pd(OAc)2 / acetonitrile / 12 h / 80 °C

4.1: 93 percent / H₂; Rh[(COD)-(S,S)-Et-DuPhos]⁽¹⁺⁾*TfO^(1-) / CH₂Cl₂; methanol / 72 h / 20 °C / 5171.48 Torr

5.1: 93 percent / aq. LiOH / methanol; tetrahydrofuran / 11 h / 20 °C

6.1: 82 percent / sodium hydride / tetrahydrofuran / 15 h / 20 °C

7.1: BOPCl; TEA / CH₂Cl₂ / 72 h / 20 °C

8.1: DDQ; aq. buffer / CH₂Cl₂ / 0.5 h / 20 °C / pH 7.00

9.1: 84 percent / Dess-Martin periodinane; 2,6-lutidine / CH₂Cl₂ / 12 h / 20 °C

10.1: 59 percent / HCO₂H / 0.2 h / 100 °C

11.1: NaBH₄ / tetrahydrofuran; H₂O / 2 h / 20 °C

12.1: 80 percent / acetic acid; Bu₃SnH; (Ph₃P)2PdCl₂ / CH₂Cl₂ / 0.5 h / 20 °C

13.1: p-TsOH; MgSO₄ / benzene / 4 h / 85 °C

14.1: H₂ / Pd/C / ethyl acetate / 760 Torr

15.1: aq. Fremy salt; KH₂PO₄ / acetonitrile

With 2,6-dimethylpyridine; bis-triphenylphosphine-palladium(II) chloride; lithium hydroxide; sodium tetrahydroborate; potassium dihydrogenphosphate; formic acid; potassiuim nitrosodisulfonate; (+)-1,2-bis((2S,,5S)-2,5-diethylphospholano)benzene(cyclooctadiene)rhodium(I) trifluoromethanesulfonate; TEA; tetrabutylammomium bromide; hydrogen; tri-n-butyl-tin hydride; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; sodium hydride; magnesium sulfate; potassium carbonate; Dess-Martin periodane; toluene-4-sulfonic acid; acetic acid; tris-(o-tolyl)phosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; palladium diacetate; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetone; acetonitrile; benzene; 3.1: Jeffery-Heck coupling;

DOI:10.1021/ja050203t

Reference yield:

toluene-4-sulfonic acid 5-iodo-2-methoxy-3-methyl-phenyl ester (351380-16-0) → C32H30N2O8 (851121-92-1)

Guidance literature:

Multi-step reaction with 17 steps

1.1: 90 percent / aq. NaOH / ethane-1,2-diol / 5 h / Heating

2.1: Et₂AlCl / CH₂Cl₂ / 1 h / 20 °C

2.2: 86 percent / CH₂Cl₂ / 24 h / 20 °C

3.1: 85 percent / K₂CO₃ / acetone / 4 h / Heating

4.1: sodium hydride / tetrahydrofuran; dimethylformamide / 0.17 h / 0 °C

4.2: 99 percent / TBAI / tetrahydrofuran; dimethylformamide / 12 h / 20 °C

5.1: 87 percent / TEA; TBABr; (o-tolyl)3P / Pd(OAc)2 / acetonitrile / 12 h / 80 °C

6.1: 93 percent / H₂; Rh[(COD)-(S,S)-Et-DuPhos]⁽¹⁺⁾*TfO^(1-) / CH₂Cl₂; methanol / 72 h / 20 °C / 5171.48 Torr

7.1: 93 percent / aq. LiOH / methanol; tetrahydrofuran / 11 h / 20 °C

8.1: 82 percent / sodium hydride / tetrahydrofuran / 15 h / 20 °C

9.1: BOPCl; TEA / CH₂Cl₂ / 72 h / 20 °C

10.1: DDQ; aq. buffer / CH₂Cl₂ / 0.5 h / 20 °C / pH 7.00

11.1: 84 percent / Dess-Martin periodinane; 2,6-lutidine / CH₂Cl₂ / 12 h / 20 °C

12.1: 59 percent / HCO₂H / 0.2 h / 100 °C

13.1: NaBH₄ / tetrahydrofuran; H₂O / 2 h / 20 °C

14.1: 80 percent / acetic acid; Bu₃SnH; (Ph₃P)2PdCl₂ / CH₂Cl₂ / 0.5 h / 20 °C

15.1: p-TsOH; MgSO₄ / benzene / 4 h / 85 °C

16.1: H₂ / Pd/C / ethyl acetate / 760 Torr

17.1: aq. Fremy salt; KH₂PO₄ / acetonitrile

With 2,6-dimethylpyridine; bis-triphenylphosphine-palladium(II) chloride; lithium hydroxide; sodium hydroxide; sodium tetrahydroborate; potassium dihydrogenphosphate; formic acid; potassiuim nitrosodisulfonate; (+)-1,2-bis((2S,,5S)-2,5-diethylphospholano)benzene(cyclooctadiene)rhodium(I) trifluoromethanesulfonate; TEA; tetrabutylammomium bromide; hydrogen; tri-n-butyl-tin hydride; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; diethylaluminium chloride; sodium hydride; magnesium sulfate; potassium carbonate; Dess-Martin periodane; toluene-4-sulfonic acid; acetic acid; tris-(o-tolyl)phosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; palladium diacetate; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; water; ethylene glycol; ethyl acetate; N,N-dimethyl-formamide; acetone; acetonitrile; benzene; 5.1: Jeffery-Heck coupling;

DOI:10.1021/ja050203t

Reference yield:

(2-benzyloxy-6-iodo-3-methoxy-4-methyl-phenyl)-methanol (351378-64-8) → C32H30N2O8 (851121-92-1)

Guidance literature:

Multi-step reaction with 14 steps

1.1: sodium hydride / tetrahydrofuran; dimethylformamide / 0.17 h / 0 °C

1.2: 99 percent / TBAI / tetrahydrofuran; dimethylformamide / 12 h / 20 °C

2.1: 87 percent / TEA; TBABr; (o-tolyl)3P / Pd(OAc)2 / acetonitrile / 12 h / 80 °C

3.1: 93 percent / H₂; Rh[(COD)-(S,S)-Et-DuPhos]⁽¹⁺⁾*TfO^(1-) / CH₂Cl₂; methanol / 72 h / 20 °C / 5171.48 Torr

4.1: 93 percent / aq. LiOH / methanol; tetrahydrofuran / 11 h / 20 °C

5.1: 82 percent / sodium hydride / tetrahydrofuran / 15 h / 20 °C

6.1: BOPCl; TEA / CH₂Cl₂ / 72 h / 20 °C

7.1: DDQ; aq. buffer / CH₂Cl₂ / 0.5 h / 20 °C / pH 7.00

8.1: 84 percent / Dess-Martin periodinane; 2,6-lutidine / CH₂Cl₂ / 12 h / 20 °C

9.1: 59 percent / HCO₂H / 0.2 h / 100 °C

10.1: NaBH₄ / tetrahydrofuran; H₂O / 2 h / 20 °C

11.1: 80 percent / acetic acid; Bu₃SnH; (Ph₃P)2PdCl₂ / CH₂Cl₂ / 0.5 h / 20 °C

12.1: p-TsOH; MgSO₄ / benzene / 4 h / 85 °C

13.1: H₂ / Pd/C / ethyl acetate / 760 Torr

14.1: aq. Fremy salt; KH₂PO₄ / acetonitrile

With 2,6-dimethylpyridine; bis-triphenylphosphine-palladium(II) chloride; lithium hydroxide; sodium tetrahydroborate; potassium dihydrogenphosphate; formic acid; potassiuim nitrosodisulfonate; (+)-1,2-bis((2S,,5S)-2,5-diethylphospholano)benzene(cyclooctadiene)rhodium(I) trifluoromethanesulfonate; TEA; tetrabutylammomium bromide; hydrogen; tri-n-butyl-tin hydride; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; sodium hydride; magnesium sulfate; Dess-Martin periodane; toluene-4-sulfonic acid; acetic acid; tris-(o-tolyl)phosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; palladium diacetate; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; benzene; 2.1: Jeffery-Heck coupling;

DOI:10.1021/ja050203t

upstream raw materials:

2-hydroxymethyl-3-iodo-6-methoxy-5-methyl-phenol

toluene-4-sulfonic acid 5-iodo-2-methoxy-3-methyl-phenyl ester

(2-benzyloxy-6-iodo-3-methoxy-4-methyl-phenyl)-methanol

2-hydroxy-5-iodo-3-methylphenyl 4-methylbenzenesulfonate

Downstream raw materials:

C₃₂H₃₀N₂O₉