2-Nitro 4' Chloro Diphenyl Ether

Base Information

• Chemical Name: 2-Nitro 4' Chloro Diphenyl Ether
• CAS No.: 91-39-4
• Molecular Formula: C12H8ClNO3
• Molecular Weight: 249.653
• Hs Code.: 2909309090
• Mol file: 91-39-4.mol

Synonyms:Ether,4-chloro-2-nitrophenyl phenyl (8CI);4-Chloro-2-nitro-1-phenoxybenzene;4-Chloro-2-nitrodiphenyl ether;4-Chloro-2-nitrophenyl phenyl ether;

Chemical Property of 2-Nitro 4' Chloro Diphenyl Ether

Chemical Property:

• Vapor Pressure: 0.000247mmHg at 25°C
• Melting Point: 36-37 ºC
• Refractive Index: 1.614
• Boiling Point: 334.5 °C at 760 mmHg
• Flash Point: 156.1 °C
• PSA: 55.05000
• Density: 1.358 g/cm³
• LogP: 4.56370
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

2-Nitro-4-chlorodiphenylEther ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 2-Nitro-4-chloro-diphenyl Ether is used in the synthesis of TR inhibitors.

Technology Process of 2-Nitro 4' Chloro Diphenyl Ether

There total 5 articles about 2-Nitro 4' Chloro Diphenyl Ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2,5-dichloronitrobenzene (89-61-2) + phenol (108-95-2,27073-41-2) → 4-chloro-2-nitro-1-phenoxybenzene (91-39-4)

Guidance literature:

With potassium hydroxide; In dimethyl sulfoxide;

DOI:10.1021/cb500789h

Reference yield: 74.0%

2-chloro-5-bromonitrobenzene (41513-04-6) + phenol (108-95-2,27073-41-2) → 4-chloro-2-nitro-1-phenoxybenzene (91-39-4)

Guidance literature:

With sodium carbonate; In N,N-dimethyl-formamide; at 85 ℃;

Reference yield:

2,5-dichloronitrobenzene (89-61-2) → 4-chloro-2-nitro-1-phenoxybenzene (91-39-4)

Guidance literature:

at 150 ℃;

upstream raw materials:

sodium phenoxide

2,5-dichloronitrobenzene

phenol

2-chloro-5-bromonitrobenzene

Downstream raw materials:

5-chloro-2-phenoxyaniline

(4-bromo-phenyl)-(4-chloro-2-nitro-phenyl)-ether

5-chloro-2-phenoxyphenylisocyanate

3-Bromo-N-(5-chloro-2-phenoxy-phenyl)-propionamide

Refernces

• 1、 Braun, Joachim,M?ckel, Martin M.,Strittmatter, Tobias,Marx, Andreas,Groth, Ulrich,Mayer, Thomas U.. "Synthesis and biological evaluation of optimized inhibitors of the mitotic kinesin Kif18A". . p. 554 - 560. Retrieved 2015/04/21.
• 2、 Wagh,Patil,Jain,Harak,Wagh. "Synthesis and evaluation of antipsychotic activity of 11-(4-aryl-1- piperazinyl)-dibenz [b, f][1,4] oxazepines and their 8-chloro analogues". . p. 165 - 172. Retrieved 2008/02/12.