2-Nitro 4' Chloro Diphenyl Ether

Base Information

• Chemical Name: 2-Nitro 4' Chloro Diphenyl Ether
• CAS No.: 91-39-4
• Molecular Formula: C12H8ClNO3
• Molecular Weight: 249.653
• Hs Code.: 2909309090
• Mol file: 91-39-4.mol

Synonyms:Ether,4-chloro-2-nitrophenyl phenyl (8CI);4-Chloro-2-nitro-1-phenoxybenzene;4-Chloro-2-nitrodiphenyl ether;4-Chloro-2-nitrophenyl phenyl ether;

Chemical Property of 2-Nitro 4' Chloro Diphenyl Ether

Chemical Property:

• Vapor Pressure: 0.000247mmHg at 25°C
• Melting Point: 36-37 ºC
• Refractive Index: 1.614
• Boiling Point: 334.5 °C at 760 mmHg
• Flash Point: 156.1 °C
• PSA: 55.05000
• Density: 1.358 g/cm³
• LogP: 4.56370
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

2-Nitro-4-chlorodiphenylEther ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 2-Nitro-4-chloro-diphenyl Ether is used in the synthesis of TR inhibitors.

Technology Process of 2-Nitro 4' Chloro Diphenyl Ether

There total 5 articles about 2-Nitro 4' Chloro Diphenyl Ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2,5-dichloronitrobenzene (89-61-2) + phenol (108-95-2,27073-41-2) → 4-chloro-2-nitro-1-phenoxybenzene (91-39-4)

Guidance literature:

With potassium hydroxide; In dimethyl sulfoxide;

DOI:10.1021/cb500789h

Reference yield: 74.0%

2-chloro-5-bromonitrobenzene (41513-04-6) + phenol (108-95-2,27073-41-2) → 4-chloro-2-nitro-1-phenoxybenzene (91-39-4)

Guidance literature:

With sodium carbonate; In N,N-dimethyl-formamide; at 85 ℃;

Reference yield:

2,5-dichloronitrobenzene (89-61-2) → 4-chloro-2-nitro-1-phenoxybenzene (91-39-4)

Guidance literature:

at 150 ℃;

upstream raw materials:

sodium phenoxide

2,5-dichloronitrobenzene

phenol

2-chloro-5-bromonitrobenzene

Downstream raw materials:

5-chloro-2-phenoxyaniline

(4-bromo-phenyl)-(4-chloro-2-nitro-phenyl)-ether

5-chloro-2-phenoxyphenylisocyanate

3-Bromo-N-(5-chloro-2-phenoxy-phenyl)-propionamide

Refernces

Practical synthetic approaches to intermediates for the preparations of the novel O-sulfonated-N-hydroxy-2-azetidinone antibiotics

10.1016/S0040-4020(01)92150-7

The research focuses on the practical synthesis of intermediates for the preparation of novel 0-sulfonated-N-hydroxy-2-azetidinone antibiotics, which are a class of monocyclic β-lactam antibiotics. The purpose of the study was to develop a simplified and commercially viable synthetic approach to key intermediates for the preparation of these antibiotics, including nocardicins, monobactams, and the new 0-sulfonated N-hydroxy-2-azetidinone antibiotics. The researchers achieved this by hydroxaminolysis of N-protected serine esters to produce hydroxamic acids, followed by acylation and cyclization to yield β-lactams. The process also involved solvolytic deacylation to obtain the parent N-hydroxy-2-azetidinones, which could be further converted to N-unsubstituted 2-azetidinones or the novel 0-sulfonated antibiotics. The chemicals used in the process included N-protected serine esters, hydroxylamine, acyl groups, and various reagents for cyclization and purification steps, such as pyridine-SO3 for the final step to produce the 0-sulfonated N-hydroxy-2-azetidinones. The conclusions of the research indicated that the developed synthetic approach was practical, did not require expensive reagents, and minimized the use of chromatography, making it a potentially commercially viable method for producing these antibiotics.