methyl [5-(5-carbamimidoyl-1H-benzimidazol-2-yl)-6-hydroxy-2′-methoxy-5′-sulfamoylbiphenyl-3-yl]acetate

Base Information

Chemical Name:methyl [5-(5-carbamimidoyl-1H-benzimidazol-2-yl)-6-hydroxy-2′-methoxy-5′-sulfamoylbiphenyl-3-yl]acetate
CAS No.:871266-66-9
Molecular Formula:C₂₄H₂₃N₅O₆S
Molecular Weight:509.543
Hs Code.:

Synonyms:methyl [5-(5-carbamimidoyl-1H-benzimidazol-2-yl)-6-hydroxy-2′-methoxy-5′-sulfamoylbiphenyl-3-yl]acetate

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Chemical Property of methyl [5-(5-carbamimidoyl-1H-benzimidazol-2-yl)-6-hydroxy-2′-methoxy-5′-sulfamoylbiphenyl-3-yl]acetate

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Technology Process of methyl [5-(5-carbamimidoyl-1H-benzimidazol-2-yl)-6-hydroxy-2′-methoxy-5′-sulfamoylbiphenyl-3-yl]acetate

There total 18 articles about methyl [5-(5-carbamimidoyl-1H-benzimidazol-2-yl)-6-hydroxy-2′-methoxy-5′-sulfamoylbiphenyl-3-yl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 871266-65-8
methyl [5'-N-tert-butylsulfamoyl-5-(5-carbamimidoyl-1H-benzimidazol-2-yl)-6-hydroxy-2'-methoxybiphenyl-3-yl]acetate

: 871266-66-9
methyl [5-(5-carbamimidoyl-1H-benzimidazol-2-yl)-6-hydroxy-2′-methoxy-5′-sulfamoylbiphenyl-3-yl]acetate

Guidance literature:: With trifluoroacetic acid; at 20 ℃; for 1.5h;

Reference yield:

: 871266-64-7
methyl [5'-N-tert-butylsulfamoyl-5-formyl-6-hydroxy-2'-methoxybiphenyl-3-yl]acetate

: 871266-66-9
methyl [5-(5-carbamimidoyl-1H-benzimidazol-2-yl)-6-hydroxy-2′-methoxy-5′-sulfamoylbiphenyl-3-yl]acetate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium metabisulfite / isopropyl alcohol / 2.5 h / 60 °C

2: oxygen / water; isopropyl alcohol / 19 h / 60 °C

3: trifluoroacetic acid / 1.5 h / 20 °C

With sodium metabisulfite; oxygen; trifluoroacetic acid; In water; isopropyl alcohol;

Reference yield:

: 61874-04-2
(3-formyl-4-hydroxyphenyl)acetic acid methyl ester

: 871266-66-9
methyl [5-(5-carbamimidoyl-1H-benzimidazol-2-yl)-6-hydroxy-2′-methoxy-5′-sulfamoylbiphenyl-3-yl]acetate

Guidance literature:: Multi-step reaction with 7 steps

1: N-Bromosuccinimide / N,N-dimethyl-formamide / 4 h / 5 - 20 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

3: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; diisopropylamine / tetrahydrofuran / 16 h / 70 °C / Inert atmosphere

4: water; hydrogenchloride / methanol / 20 - 25 °C

5: sodium metabisulfite / isopropyl alcohol / 2.5 h / 60 °C

6: oxygen / water; isopropyl alcohol / 19 h / 60 °C

7: trifluoroacetic acid / 1.5 h / 20 °C

With hydrogenchloride; sodium metabisulfite; N-Bromosuccinimide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; water; oxygen; diisopropylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol;