2-methoxy-4-vinylphenyltrifluoromethane sulfonate

Base Information

• Chemical Name: 2-methoxy-4-vinylphenyltrifluoromethane sulfonate
• CAS No.: 1342818-06-7
• Molecular Formula: C₁₀H₉F₃O₄S
• Molecular Weight: 282.24
• Mol file: 1342818-06-7.mol

Synonyms:2-methoxy-4-vinylphenyltrifluoromethane sulfonate

Chemical Property of 2-methoxy-4-vinylphenyltrifluoromethane sulfonate

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-methoxy-4-vinylphenyltrifluoromethane sulfonate

There total 1 articles about 2-methoxy-4-vinylphenyltrifluoromethane sulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

trifluoromethylsulfonic anhydride (358-23-6) + 3-methoxy-4-hydroxystyrene (7786-61-0,31853-85-7) → 2-methoxy-4-vinylphenyltrifluoromethane sulfonate (1342818-06-7)

Guidance literature:

With pyridine; In dichloromethane; at 0 ℃; for 4h; Inert atmosphere;

DOI:10.1002/chem.201101550

Reference yield:

2-methoxy-4-vinylphenyltrifluoromethane sulfonate (1342818-06-7) → 2',4-dimethoxy-4'-[2-(3-(4-formylphenoxy)-4-methoxyphenyl)vinyl]biphenyl-2-carbaldehyde

Guidance literature:

Multi-step reaction with 2 steps

1: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; caesium carbonate; lithium chloride; palladium dichloride / 1,4-dioxane / 3 h / Inert atmosphere; Reflux

2: palladium diacetate; triethylamine / 1,4-dioxane / 19 h / Inert atmosphere; Reflux

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; caesium carbonate; triethylamine; lithium chloride; palladium dichloride; In 1,4-dioxane; 1: Suzuki-Miyaura coupling / 2: Heck reaction;

DOI:10.1002/chem.201101550

Reference yield:

2-methoxy-4-vinylphenyltrifluoromethane sulfonate (1342818-06-7) → 2',4-dimethoxy-4'-{2-[3-(4-formylphenoxy)-4-methoxyphenyl]ethyl}biphenyl-2-carbaldehyde (1342818-09-0)

Guidance literature:

Multi-step reaction with 3 steps

1: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; caesium carbonate; lithium chloride; palladium dichloride / 1,4-dioxane / 3 h / Inert atmosphere; Reflux

2: palladium diacetate; triethylamine / 1,4-dioxane / 19 h / Inert atmosphere; Reflux

3: 5%-palladium/activated carbon; hydrogen / tetrahydrofuran / 0.17 h

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; 5%-palladium/activated carbon; hydrogen; palladium diacetate; caesium carbonate; triethylamine; lithium chloride; palladium dichloride; In tetrahydrofuran; 1,4-dioxane; 1: Suzuki-Miyaura coupling / 2: Heck reaction;

DOI:10.1002/chem.201101550

upstream raw materials:

trifluoromethylsulfonic anhydride

3-methoxy-4-hydroxystyrene

Downstream raw materials:

2',4-dimethoxy-4'-{2-[3-(4-formylphenoxy)-4-methoxyphenyl]ethyl}biphenyl-2-carbaldehyde

2',4-dimethoxy-4'-{2-[3-(4-hydroxymethylphenoxy)-4-methoxyphenyl]ethyl}biphenyl-2-carbaldehyde

Br^(1-)*C₄₉H₄₄O₅P⁽¹⁺⁾

2',4-dimethoxy-2-vinyl-4'-{2-[3-(4-vinylphenoxy)-4-methoxyphenyl]ethyl}biphenyl