2',4-dimethoxy-4'-{2-[3-(4-hydroxymethylphenoxy)-4-methoxyphenyl]ethyl}biphenyl-2-carbaldehyde

Base Information

Chemical Name:2',4-dimethoxy-4'-{2-[3-(4-hydroxymethylphenoxy)-4-methoxyphenyl]ethyl}biphenyl-2-carbaldehyde
CAS No.:1342818-10-3
Molecular Formula:C₃₁H₃₀O₆
Molecular Weight:498.576
Hs Code.:

Synonyms:2',4-dimethoxy-4'-{2-[3-(4-hydroxymethylphenoxy)-4-methoxyphenyl]ethyl}biphenyl-2-carbaldehyde

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Chemical Property of 2',4-dimethoxy-4'-{2-[3-(4-hydroxymethylphenoxy)-4-methoxyphenyl]ethyl}biphenyl-2-carbaldehyde

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Technology Process of 2',4-dimethoxy-4'-{2-[3-(4-hydroxymethylphenoxy)-4-methoxyphenyl]ethyl}biphenyl-2-carbaldehyde

There total 8 articles about 2',4-dimethoxy-4'-{2-[3-(4-hydroxymethylphenoxy)-4-methoxyphenyl]ethyl}biphenyl-2-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 2',4-dimethoxy-4'-[2-(3-(4-formylphenoxy)-4-methoxyphenyl)vinyl]biphenyl-2-carbaldehyde

: 1342818-10-3
2',4-dimethoxy-4'-{2-[3-(4-hydroxymethylphenoxy)-4-methoxyphenyl]ethyl}biphenyl-2-carbaldehyde

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; dichloromethane; for 0.333333h;
DOI:10.1002/chem.201101550

Reference yield:

: 1342818-06-7
2-methoxy-4-vinylphenyltrifluoromethane sulfonate

: 1342818-10-3
2',4-dimethoxy-4'-{2-[3-(4-hydroxymethylphenoxy)-4-methoxyphenyl]ethyl}biphenyl-2-carbaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; caesium carbonate; lithium chloride; palladium dichloride / 1,4-dioxane / 3 h / Inert atmosphere; Reflux

2: palladium diacetate; triethylamine / 1,4-dioxane / 19 h / Inert atmosphere; Reflux

3: palladium 10% on activated carbon; hydrogen / methanol; dichloromethane / 0.33 h

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium 10% on activated carbon; hydrogen; palladium diacetate; caesium carbonate; triethylamine; lithium chloride; palladium dichloride; In 1,4-dioxane; methanol; dichloromethane; 1: Suzuki-Miyaura coupling / 2: Heck reaction;
DOI:10.1002/chem.201101550

Reference yield:

: 7786-61-0,31853-85-7
3-methoxy-4-hydroxystyrene

: 1342818-10-3
2',4-dimethoxy-4'-{2-[3-(4-hydroxymethylphenoxy)-4-methoxyphenyl]ethyl}biphenyl-2-carbaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / dichloromethane / 4 h / 0 °C / Inert atmosphere

2: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; caesium carbonate; lithium chloride; palladium dichloride / 1,4-dioxane / 3 h / Inert atmosphere; Reflux

3: palladium diacetate; triethylamine / 1,4-dioxane / 19 h / Inert atmosphere; Reflux

4: palladium 10% on activated carbon; hydrogen / methanol; dichloromethane / 0.33 h

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; pyridine; palladium 10% on activated carbon; hydrogen; palladium diacetate; caesium carbonate; triethylamine; lithium chloride; palladium dichloride; In 1,4-dioxane; methanol; dichloromethane; 2: Suzuki-Miyaura coupling / 3: Heck reaction;
DOI:10.1002/chem.201101550