2-(Chloromethyl)-1-phenyl-1H-benzimidazole

Base Information

• Chemical Name: 2-(Chloromethyl)-1-phenyl-1H-benzimidazole
• CAS No.: 94937-86-7
• Molecular Formula: C14H11ClN2
• Molecular Weight: 242.708
• DSSTox Substance ID: DTXSID50604133
• Wikidata: Q82501893
• Mol file: 94937-86-7.mol

Synonyms:94937-86-7;2-(CHLOROMETHYL)-1-PHENYL-1H-BENZIMIDAZOLE;2-(chloromethyl)-1-phenyl-1H-benzo[d]imidazole;2-CHLOROMETHYL-1-PHENYL-1H-BENZOIMIDAZOLE;2-(chloromethyl)-1-phenylbenzimidazole;MFCD04114570;1H-BENZIMIDAZOLE, 2-(CHLOROMETHYL)-1-PHENYL-;SCHEMBL259639;DTXSID50604133;TYOBCMJTBPLYGR-UHFFFAOYSA-N;AKOS009275187;AB18569;2-(chloromethyl)-1-phenyl-benzimidazole;2-chloromethyl-1-phenyl-1H-benzimidazole;AS-31328;SY023615;DB-022565;SL-000156;A845135;2-(CHLOROMETHYL)-1-PHENYL-1H-1,3-BENZODIAZOLE

Chemical Property of 2-(Chloromethyl)-1-phenyl-1H-benzimidazole

Chemical Property:

• Boiling Point: 408.9 °C at 760 mmHg
• Flash Point: 201.1 °C
• PSA: 17.82000
• Density: 1.23 g/cm³
• LogP: 3.76430
• XLogP3: 3.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 242.0610761
• Heavy Atom Count: 17
• Complexity: 253

Purity/Quality:

99%, ^*data from raw suppliers

2-(Chloromethyl)-1-phenyl-1H-benzimidazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)N2C3=CC=CC=C3N=C2CCl

Technology Process of 2-(Chloromethyl)-1-phenyl-1H-benzimidazole

There total 11 articles about 2-(Chloromethyl)-1-phenyl-1H-benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

2-chloromethyl-1H-benzimidazole (4857-04-9) + phenylboronic acid (98-80-6) → 2-(chloromethyl)-1-phenyl-1H-benzo[d]imidazole (94937-86-7)

Guidance literature:

With C₂₀H₂₈CuN₄O₄⁽²⁺⁾*2Cl₄Cu^(2-)*C₂₂H₃₆CuN₄O₆⁽²⁺⁾; In methanol; at 20 ℃; for 22h; Schlenk technique;

DOI:10.1039/c8ob02254b

Reference yield: 68.0%

chloroacetyl chloride (79-04-9) + N-phenyl-1,2-benzenediamine (534-85-0) → 2-(chloromethyl)-1-phenyl-1H-benzo[d]imidazole (94937-86-7)

Guidance literature:

In N,N-dimethyl-formamide; at 80 ℃; for 2h;

DOI:10.1016/j.bmc.2018.04.029

Reference yield:

2-chloro-N-[2-(phenylamino)phenyl]-acetamide (94937-85-6) → 2-(chloromethyl)-1-phenyl-1H-benzo[d]imidazole (94937-86-7)

Guidance literature:

With p-toluenesulfonic acid monohydrate; In benzene;

upstream raw materials:

2-chloro-N-[2-(phenylamino)phenyl]-acetamide

2-nitro-N-phenylaniline

chloroacetyl chloride

N-phenyl-1,2-benzenediamine

Downstream raw materials:

2-(1H-1,2,4-triazol-1-yl)methyl-1-phenyl-1H-benzimidazole

9-((1-phenyl-1H-benzo[d]imidazol-2-yl)methyl)-9H-purin-6-amine

3-iodo-1-((1-phenyl-1H-benzo[d]imidazol-2-yl)methyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

4-chloro-1-(1-phenyl-1H-benzoimidazol-2-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-6-ylamine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 94937-86-7 2-CHLOROMETHYL-1-PHENYL-1H-BENZOIMIDAZOLE

Send

Send

Metric Ton KG G Pound L ML

Send

Send