7'-{3,4-bis[2-(1,3-dioxolanyl)]-benzoylamino}-3-{3,4-bis[2-(1,3-dioxolanyl)]-benzyloxy}-17-(cyclopropylmethyl)-6,7-didehydro-4,5α-epoxy-14-hydroxyindolo[2',3':6,7]-morphinan

Base Information

• Chemical Name: 7'-{3,4-bis[2-(1,3-dioxolanyl)]-benzoylamino}-3-{3,4-bis[2-(1,3-dioxolanyl)]-benzyloxy}-17-(cyclopropylmethyl)-6,7-didehydro-4,5α-epoxy-14-hydroxyindolo[2',3':6,7]-morphinan
• CAS No.: 336129-82-9
• Molecular Formula: C₅₂H₅₁N₃O₁₃
• Molecular Weight: 925.989
• Mol file: 336129-82-9.mol

Synonyms:7'-{3,4-bis[2-(1,3-dioxolanyl)]-benzoylamino}-3-{3,4-bis[2-(1,3-dioxolanyl)]-benzyloxy}-17-(cyclopropylmethyl)-6,7-didehydro-4,5α-epoxy-14-hydroxyindolo[2',3':6,7]-morphinan

Chemical Property of 7'-{3,4-bis[2-(1,3-dioxolanyl)]-benzoylamino}-3-{3,4-bis[2-(1,3-dioxolanyl)]-benzyloxy}-17-(cyclopropylmethyl)-6,7-didehydro-4,5α-epoxy-14-hydroxyindolo[2',3':6,7]-morphinan

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7'-{3,4-bis[2-(1,3-dioxolanyl)]-benzoylamino}-3-{3,4-bis[2-(1,3-dioxolanyl)]-benzyloxy}-17-(cyclopropylmethyl)-6,7-didehydro-4,5α-epoxy-14-hydroxyindolo[2',3':6,7]-morphinan

There total 4 articles about 7'-{3,4-bis[2-(1,3-dioxolanyl)]-benzoylamino}-3-{3,4-bis[2-(1,3-dioxolanyl)]-benzyloxy}-17-(cyclopropylmethyl)-6,7-didehydro-4,5α-epoxy-14-hydroxyindolo[2',3':6,7]-morphinan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

7'-aminonaltrindole (143619-57-2) + 3,4-bis-[2-(1,3-dioxolanyl)]-benzoic acid (943600-47-3) → 7'-{3,4-bis[2-(1,3-dioxolanyl)]-benzoylamino}-3-{3,4-bis[2-(1,3-dioxolanyl)]-benzyloxy}-17-(cyclopropylmethyl)-6,7-didehydro-4,5α-epoxy-14-hydroxyindolo[2',3':6,7]-morphinan (336129-82-9)

Guidance literature:

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 20 ℃; for 120h;

DOI:10.1021/jm061194h

Reference yield:

3,4-bis(dibromomethyl)benzoic acid (19047-21-3) → 7'-{3,4-bis[2-(1,3-dioxolanyl)]-benzoylamino}-3-{3,4-bis[2-(1,3-dioxolanyl)]-benzyloxy}-17-(cyclopropylmethyl)-6,7-didehydro-4,5α-epoxy-14-hydroxyindolo[2',3':6,7]-morphinan (336129-82-9)

Guidance literature:

Multi-step reaction with 3 steps

1: aq. Na₂CO₃ / 2.5 h / 70 °C

2: p-toluenesulfonic acid / Heating

3: 67 percent / DCC; HOBt / dimethylformamide / 120 h / 20 °C

With sodium carbonate; benzotriazol-1-ol; toluene-4-sulfonic acid; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide;

DOI:10.1021/jm061194h

Reference yield:

3,4-diformylbenzoic acid (19047-22-4) → 7'-{3,4-bis[2-(1,3-dioxolanyl)]-benzoylamino}-3-{3,4-bis[2-(1,3-dioxolanyl)]-benzyloxy}-17-(cyclopropylmethyl)-6,7-didehydro-4,5α-epoxy-14-hydroxyindolo[2',3':6,7]-morphinan (336129-82-9)

Guidance literature:

Multi-step reaction with 2 steps

1: p-toluenesulfonic acid / Heating

2: 67 percent / DCC; HOBt / dimethylformamide / 120 h / 20 °C

With benzotriazol-1-ol; toluene-4-sulfonic acid; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide;

DOI:10.1021/jm061194h

upstream raw materials:

7'-aminonaltrindole

3,4-bis-[2-(1,3-dioxolanyl)]-benzoic acid

3,4-bis(dibromomethyl)benzoic acid

3,4-diformylbenzoic acid