(E)-(R)-7-(tert-Butyl-diphenyl-silanyloxy)-3-(4-methoxy-benzyloxy)-hept-5-en-2-one

Base Information

Chemical Name:(E)-(R)-7-(tert-Butyl-diphenyl-silanyloxy)-3-(4-methoxy-benzyloxy)-hept-5-en-2-one
CAS No.:372511-38-1
Molecular Formula:C₃₁H₃₈O₄Si
Molecular Weight:502.726
Hs Code.:

Synonyms:(E)-(R)-7-(tert-Butyl-diphenyl-silanyloxy)-3-(4-methoxy-benzyloxy)-hept-5-en-2-one

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Chemical Property of (E)-(R)-7-(tert-Butyl-diphenyl-silanyloxy)-3-(4-methoxy-benzyloxy)-hept-5-en-2-one

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Technology Process of (E)-(R)-7-(tert-Butyl-diphenyl-silanyloxy)-3-(4-methoxy-benzyloxy)-hept-5-en-2-one

There total 10 articles about (E)-(R)-7-(tert-Butyl-diphenyl-silanyloxy)-3-(4-methoxy-benzyloxy)-hept-5-en-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 89238-99-3
O-(4-methoxybenzyl)-trichloroacetimidate

: 372511-38-1
(E)-(R)-7-(tert-Butyl-diphenyl-silanyloxy)-3-(4-methoxy-benzyloxy)-hept-5-en-2-one

Guidance literature:: Multi-step reaction with 10 steps

1: TfOH / diethyl ether

2: LiAlH₄ / tetrahydrofuran

3: iPr₂NEt; LiCl / acetonitrile

4: DIBAL / CH₂Cl₂ / -78 °C

5: imidazole / CH₂Cl₂

6: p-TsOH / methanol

With 1H-imidazole; lithium aluminium tetrahydride; trifluorormethanesulfonic acid; diisobutylaluminium hydride; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; lithium chloride; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; acetonitrile; 3: Dess-Martin oxidation / 4: Horner-Wadsworth-Emmons olefination / 8: Swern oxidation / 9: Grignard reaction / 10: Swern oxidation;
DOI:10.1021/ol010150u

Reference yield:

: 740852-94-2
(3R)-4-tert-butyldimethylsilyloxy-3-(4-methoxybenzyloxy)butanal

: 372511-38-1
(E)-(R)-7-(tert-Butyl-diphenyl-silanyloxy)-3-(4-methoxy-benzyloxy)-hept-5-en-2-one

Guidance literature:: Multi-step reaction with 7 steps

1: iPr₂NEt; LiCl / acetonitrile

2: DIBAL / CH₂Cl₂ / -78 °C

3: imidazole / CH₂Cl₂

4: p-TsOH / methanol

With 1H-imidazole; diisobutylaluminium hydride; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; lithium chloride; In methanol; dichloromethane; acetonitrile; 1: Horner-Wadsworth-Emmons olefination / 5: Swern oxidation / 6: Grignard reaction / 7: Swern oxidation;
DOI:10.1021/ol010150u

Reference yield:

: 372511-48-3
4-(tert-butyl-dimethyl-silanyloxy)-3-(4-methoxy-benzyloxy)-butan-1-ol

: 372511-38-1
(E)-(R)-7-(tert-Butyl-diphenyl-silanyloxy)-3-(4-methoxy-benzyloxy)-hept-5-en-2-one

Guidance literature:: Multi-step reaction with 8 steps

1: iPr₂NEt; LiCl / acetonitrile

2: DIBAL / CH₂Cl₂ / -78 °C

3: imidazole / CH₂Cl₂

4: p-TsOH / methanol

With 1H-imidazole; diisobutylaluminium hydride; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; lithium chloride; In methanol; dichloromethane; acetonitrile; 1: Dess-Martin oxidation / 2: Horner-Wadsworth-Emmons olefination / 6: Swern oxidation / 7: Grignard reaction / 8: Swern oxidation;
DOI:10.1021/ol010150u