4-Nitropyridin-2-amine

Base Information

Chemical Name:4-Nitropyridin-2-amine
CAS No.:4487-50-7
Molecular Formula:C5H5N3O2
Molecular Weight:139.114
Hs Code.:2933399090
European Community (EC) Number:636-940-9
DSSTox Substance ID:DTXSID90376483
Nikkaji Number:J3.079.496F
Wikidata:Q72440135
Mol file:4487-50-7.mol

Synonyms:4-nitropyridin-2-amine;4487-50-7;2-AMINO-4-NITROPYRIDINE;4-Nitro-pyridin-2-ylamine;MFCD04114148;4-Nitropyridine-2-amine;SCHEMBL345273;AMY5629;DTXSID90376483;DBDHHHBAZZYVJG-UHFFFAOYSA-N;AKOS010978429;AB17924;CS-W019623;PS-3669;AC-22809;SY005608;BB 0261083;FT-0602040;EN300-65513;A26266;J-515888

Suppliers and Price of 4-Nitropyridin-2-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-Nitropyridin-2-amine
50mg
$ 55.00

SynQuest Laboratories
2-Amino-4-nitropyridine
1 g
$ 154.00

Oakwood
4-Nitropyridin-2-amine 98%
1g
$ 149.00

Matrix Scientific
4-Nitropyridin-2-amine 95%
500mg
$ 217.00

Matrix Scientific
4-Nitropyridin-2-amine 95%
1g
$ 349.00

Matrix Scientific
4-Nitropyridin-2-amine 95%
5g
$ 1055.00

J&W Pharmlab
4-Nitro-pyridin-2-ylamine 97%
25g
$ 1120.00

Crysdot
4-Nitropyridin-2-amine 97+%
5g
$ 279.00

ChemScene
2-Amino-4-nitropyridine 99.81%
10g
$ 530.00

ChemScene
2-Amino-4-nitropyridine 99.81%
5g
$ 268.00

Total 68 raw suppliers

Chemical Property of 4-Nitropyridin-2-amine

Chemical Property:

Vapor Pressure:9.49E-05mmHg at 25°C
Melting Point:96 °C
Refractive Index:1.645
Boiling Point:339 °C at 760 mmHg
PKA:3.43±0.11(Predicted)
Flash Point:158.8 °C
PSA：84.73000
Density:1.437 g/cm³
LogP:1.67640
Storage Temp.:under inert gas (nitrogen or Argon) at 2–8 °C
XLogP3:0.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:0
Exact Mass:139.038176411
Heavy Atom Count:10
Complexity:133

Purity/Quality:

99%, ^*data from raw suppliers

4-Nitropyridin-2-amine ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Safety Statements: 22-24/25

MSDS Files:

Useful:

Canonical SMILES:C1=CN=C(C=C1[N+](=O)[O-])N
Uses 4-Nitropyridin-2-amine is used to synthesize tetrahydronaphthalene Raf inhibitors.

Technology Process of 4-Nitropyridin-2-amine

There total 9 articles about 4-Nitropyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 942076-74-6
N-[(4-(methoxy)phenyl)methyl]-4-nitro-pyridin2-amine

: 4487-50-7
2-amino-4-nitropyridine

Guidance literature:: N-[(4-(methoxy)phenyl)methyl]-4-nitro-pyridin2-amine; With methoxybenzene; trifluoroacetic acid; at 80 ℃; for 2h;

With sodium hydroxide;

Reference yield:

: 14432-16-7
2-chloro-4-nitropyridine-N-oxide

: 4487-50-7
2-amino-4-nitropyridine

Guidance literature:: Multi-step reaction with 4 steps

1: NH₃ / ethanol

3: PCl₃ / CHCl₃

4: H₂O, HCl

With hydrogenchloride; ammonia; water; phosphorus trichloride; In ethanol; chloroform;
DOI:10.1016/S0022-2860(97)00009-4

Reference yield:

: 942076-73-5
N-(4-methoxybenzyl)-4-nitropyridin-2-amine 1-oxide

: 4487-50-7
2-amino-4-nitropyridine

Guidance literature:: Multi-step reaction with 2 steps

1: trichlorophosphate / chloroform / 0 - 20 °C

2: methoxybenzene; trifluoroacetic acid / 2 h / 80 °C

With methoxybenzene; trifluoroacetic acid; trichlorophosphate; In chloroform;
DOI:10.1021/jm101479y