methyl 4-((6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)methyl)benzoate

Base Information

Chemical Name:methyl 4-((6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)methyl)benzoate
CAS No.:1432509-93-7
Molecular Formula:C₁₉H₁₉F₃N₂O₃
Molecular Weight:380.367
Hs Code.:

Synonyms:methyl 4-((6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)methyl)benzoate

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Chemical Property of methyl 4-((6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)methyl)benzoate

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Technology Process of methyl 4-((6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)methyl)benzoate

There total 3 articles about methyl 4-((6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)methyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 908111-34-2
6,6-dimethyl-3-(trifluoromethyl)-1,5,6,7-tetrahydro-4H-indazol-4-one

: 2417-72-3
Methyl 4-(bromomethyl)benzoate

: 1432509-93-7
methyl 4-((6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)methyl)benzoate

Guidance literature:: 6,6-dimethyl-3-(trifluoromethyl)-1,5,6,7-tetrahydro-4H-indazol-4-one; With sodium hydride; In N,N-dimethyl acetamide; for 0.0833333h;

Methyl 4-(bromomethyl)benzoate; In N,N-dimethyl acetamide; at 20 ℃; for 4h;

Reference yield:

: 41189-09-7
(Z)-N'-(3,3-dimethyl-5-oxocyclohexylidene)-4-methylbenzenesulfonohydrazide

: 1432509-93-7
methyl 4-((6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)methyl)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / tetrahydrofuran / 2 h / 55 °C

1.2: 3 h / 20 °C

2.1: sodium hydride / N,N-dimethyl acetamide / 0.08 h / 20 °C

2.2: 4 h / 20 °C

With sodium hydride; triethylamine; In tetrahydrofuran; N,N-dimethyl acetamide;

Reference yield:

: 126-81-8
dimedone

: 1432509-93-7
methyl 4-((6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)methyl)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: toluene-4-sulfonic acid / toluene / 0.5 h / Reflux

2.1: triethylamine / tetrahydrofuran / 2 h / 55 °C

2.2: 3 h / 20 °C

3.1: sodium hydride / N,N-dimethyl acetamide / 0.08 h / 20 °C

3.2: 4 h / 20 °C

With sodium hydride; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; N,N-dimethyl acetamide; toluene; 1.1: |Fischer Indole Synthesis;