benzyl 2-(2-amino-2-oxoethoxy)-5-[(2S)-2-[(tert-butoxycarbonyl)amino]-3-oxo-3-(pentylamino)propyl]benzoate

Base Information

• Chemical Name: benzyl 2-(2-amino-2-oxoethoxy)-5-[(2S)-2-[(tert-butoxycarbonyl)amino]-3-oxo-3-(pentylamino)propyl]benzoate
• CAS No.: 402476-71-5
• Molecular Formula: C₂₉H₃₉N₃O₇
• Molecular Weight: 541.645
• Mol file: 402476-71-5.mol

Synonyms:benzyl 2-(2-amino-2-oxoethoxy)-5-[(2S)-2-[(tert-butoxycarbonyl)amino]-3-oxo-3-(pentylamino)propyl]benzoate

Chemical Property of benzyl 2-(2-amino-2-oxoethoxy)-5-[(2S)-2-[(tert-butoxycarbonyl)amino]-3-oxo-3-(pentylamino)propyl]benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl 2-(2-amino-2-oxoethoxy)-5-[(2S)-2-[(tert-butoxycarbonyl)amino]-3-oxo-3-(pentylamino)propyl]benzoate

There total 6 articles about benzyl 2-(2-amino-2-oxoethoxy)-5-[(2S)-2-[(tert-butoxycarbonyl)amino]-3-oxo-3-(pentylamino)propyl]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

bromo-acetic acid amide (683-57-8) + benzyl 5-[(2S)-2-[(tert-butoxycarbonyl)amino]-3-oxo-3-(pentylamino)propyl]-2-hydroxybenzoate (221077-53-8) → benzyl 2-(2-amino-2-oxoethoxy)-5-[(2S)-2-[(tert-butoxycarbonyl)amino]-3-oxo-3-(pentylamino)propyl]benzoate (402476-71-5)

Guidance literature:

With potassium carbonate; In acetone; at 40 ℃; for 16h;

DOI:10.1021/jm010393s

Reference yield:

tert-butyl (1S)-1-(4-hydroxy-3-iodobenzyl)-2-oxo-2-(pentylamino)ethylcarbamate (221077-42-5) → benzyl 2-(2-amino-2-oxoethoxy)-5-[(2S)-2-[(tert-butoxycarbonyl)amino]-3-oxo-3-(pentylamino)propyl]benzoate (402476-71-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 27 percent / Et₃N; 1,1'-bis(diphenylphosphino)ferrocene / palladium(II) acetate / dimethylformamide / 16 h / 70 °C

2: 83 percent / K₂CO₃ / acetone / 50 °C

With 1,1'-bis-(diphenylphosphino)ferrocene; potassium carbonate; triethylamine; palladium diacetate; In N,N-dimethyl-formamide; acetone;

DOI:10.1021/jm011100y

Reference yield:

benzyl alcohol (100-51-6,185532-71-2) → benzyl 2-(2-amino-2-oxoethoxy)-5-[(2S)-2-[(tert-butoxycarbonyl)amino]-3-oxo-3-(pentylamino)propyl]benzoate (402476-71-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 27 percent / Et₃N; 1,1'-bis(diphenylphosphino)ferrocene / palladium(II) acetate / dimethylformamide / 16 h / 70 °C

2: 83 percent / K₂CO₃ / acetone / 50 °C

With 1,1'-bis-(diphenylphosphino)ferrocene; potassium carbonate; triethylamine; palladium diacetate; In N,N-dimethyl-formamide; acetone;

DOI:10.1021/jm011100y

upstream raw materials:

bromo-acetic acid amide

benzyl 5-[(2S)-2-[(tert-butoxycarbonyl)amino]-3-oxo-3-(pentylamino)propyl]-2-hydroxybenzoate

benzyl alcohol

tert-butyl (1S)-1-(4-hydroxy-3-iodobenzyl)-2-oxo-2-(pentylamino)ethylcarbamate

Downstream raw materials:

5-((S)-2-Amino-2-pentylcarbamoyl-ethyl)-2-carbamoylmethoxy-benzoic acid benzyl ester