(4S,5R)-3-{[6-azetidin-1-yl-3-(5-iodo-2-methoxyphenyl)pyridin-2-yl]methyl}-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-1,3-oxazolidin-2-one

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Chemical Name:(4S,5R)-3-{[6-azetidin-1-yl-3-(5-iodo-2-methoxyphenyl)pyridin-2-yl]methyl}-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-1,3-oxazolidin-2-one
CAS No.:1374134-55-0
Molecular Formula:C₂₈H₂₄F₆IN₃O₃
Molecular Weight:691.412
Hs Code.:

Synonyms:(4S,5R)-3-{[6-azetidin-1-yl-3-(5-iodo-2-methoxyphenyl)pyridin-2-yl]methyl}-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-1,3-oxazolidin-2-one

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Chemical Property of (4S,5R)-3-{[6-azetidin-1-yl-3-(5-iodo-2-methoxyphenyl)pyridin-2-yl]methyl}-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-1,3-oxazolidin-2-one

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Technology Process of (4S,5R)-3-{[6-azetidin-1-yl-3-(5-iodo-2-methoxyphenyl)pyridin-2-yl]methyl}-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-1,3-oxazolidin-2-one

There total 9 articles about (4S,5R)-3-{[6-azetidin-1-yl-3-(5-iodo-2-methoxyphenyl)pyridin-2-yl]methyl}-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-1,3-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1374134-56-1
(4S,5R)-3-{[3-(5-amino-2-methoxyphenyl)-6-azetidin-1-ylpyridin-2-yl]methyl}-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-1,3-oxazolidin-2-one

: 1374134-55-0
(4S,5R)-3-{[6-azetidin-1-yl-3-(5-iodo-2-methoxyphenyl)pyridin-2-yl]methyl}-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-1,3-oxazolidin-2-one

Guidance literature:: With diiodomethane; isopentyl nitrite; In toluene; at 25 - 80 ℃; for 1h;

Reference yield:

: 5197-28-4
2-bromo-4-nitroanisole

: 1374134-55-0
(4S,5R)-3-{[6-azetidin-1-yl-3-(5-iodo-2-methoxyphenyl)pyridin-2-yl]methyl}-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-1,3-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / dimethyl sulfoxide / 3 h / 50 - 80 °C / Inert atmosphere

2: potassium carbonate / dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II) / tetrahydrofuran / 4 h / 25 °C / Inert atmosphere

3: hydrogen / palladium 10% on activated carbon / ethanol / 6.5 h

4: diiodomethane; isopentyl nitrite / toluene / 1 h / 25 - 80 °C

With diiodomethane; hydrogen; potassium acetate; potassium carbonate; isopentyl nitrite; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dimethyl sulfoxide; toluene;

Reference yield:

: 132606-40-7
3-bromo-6-chloro-2-methyl-pyridine

: 1374134-55-0
(4S,5R)-3-{[6-azetidin-1-yl-3-(5-iodo-2-methoxyphenyl)pyridin-2-yl]methyl}-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-1,3-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-Bromosuccinimide / 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 24 h / Reflux

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 20 °C

2.2: 16 h / 20 °C

3.1: tetrahydrofuran / 0.5 h / 150 °C / sealed tube; microwave irradiation

4.1: potassium carbonate / dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II) / tetrahydrofuran / 4 h / 25 °C / Inert atmosphere

5.1: hydrogen / palladium 10% on activated carbon / ethanol / 6.5 h

6.1: diiodomethane; isopentyl nitrite / toluene / 1 h / 25 - 80 °C

With N-Bromosuccinimide; diiodomethane; hydrogen; sodium hydride; potassium carbonate; isopentyl nitrite; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); 2,2'-azobis(isobutyronitrile); palladium 10% on activated carbon; In tetrahydrofuran; tetrachloromethane; ethanol; toluene; mineral oil;