methyl 5-{3-[6-azetidin-1-yl-2-({(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)pyridin-3-yl]-4-methoxyphenyl}-2-furoate

Base Information

Chemical Name:methyl 5-{3-[6-azetidin-1-yl-2-({(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)pyridin-3-yl]-4-methoxyphenyl}-2-furoate
CAS No.:1374131-12-0
Molecular Formula:C₃₄H₂₉F₆N₃O₆
Molecular Weight:689.611
Hs Code.:

methyl 5-{3-[6-azetidin-1-yl-2-({(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)pyridin-3-yl]-4-methoxyphenyl}-2-furoate

Synonyms:methyl 5-{3-[6-azetidin-1-yl-2-({(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)pyridin-3-yl]-4-methoxyphenyl}-2-furoate

Suppliers and Price of methyl 5-{3-[6-azetidin-1-yl-2-({(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)pyridin-3-yl]-4-methoxyphenyl}-2-furoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl 5-{3-[6-azetidin-1-yl-2-({(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)pyridin-3-yl]-4-methoxyphenyl}-2-furoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl 5-{3-[6-azetidin-1-yl-2-({(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)pyridin-3-yl]-4-methoxyphenyl}-2-furoate

There total 11 articles about methyl 5-{3-[6-azetidin-1-yl-2-({(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)pyridin-3-yl]-4-methoxyphenyl}-2-furoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 876189-20-7
(5-(methoxycarbonyl)furan-2-yl)boronic acid

: 1374134-55-0
(4S,5R)-3-{[6-azetidin-1-yl-3-(5-iodo-2-methoxyphenyl)pyridin-2-yl]methyl}-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-1,3-oxazolidin-2-one

: 1374131-12-0
methyl 5-{3-[6-azetidin-1-yl-2-({(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)pyridin-3-yl]-4-methoxyphenyl}-2-furoate

Guidance literature:: With potassium carbonate; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); In tetrahydrofuran; at 25 ℃; Inert atmosphere;

Reference yield:

: 5197-28-4
2-bromo-4-nitroanisole

: 1374131-12-0
methyl 5-{3-[6-azetidin-1-yl-2-({(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)pyridin-3-yl]-4-methoxyphenyl}-2-furoate

Guidance literature:: Multi-step reaction with 5 steps

1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / dimethyl sulfoxide / 3 h / 50 - 80 °C / Inert atmosphere

2: potassium carbonate / dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II) / tetrahydrofuran / 4 h / 25 °C / Inert atmosphere

3: hydrogen / palladium 10% on activated carbon / ethanol / 6.5 h

4: diiodomethane; isopentyl nitrite / toluene / 1 h / 25 - 80 °C

5: potassium carbonate / dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II) / tetrahydrofuran / 25 °C / Inert atmosphere

With diiodomethane; hydrogen; potassium acetate; potassium carbonate; isopentyl nitrite; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dimethyl sulfoxide; toluene;

Reference yield:

: 132606-40-7
3-bromo-6-chloro-2-methyl-pyridine

: 1374131-12-0
methyl 5-{3-[6-azetidin-1-yl-2-({(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)pyridin-3-yl]-4-methoxyphenyl}-2-furoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: N-Bromosuccinimide / 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 24 h / Reflux

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 20 °C

2.2: 16 h / 20 °C

3.1: tetrahydrofuran / 0.5 h / 150 °C / sealed tube; microwave irradiation

4.1: potassium carbonate / dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II) / tetrahydrofuran / 4 h / 25 °C / Inert atmosphere

5.1: hydrogen / palladium 10% on activated carbon / ethanol / 6.5 h

6.1: diiodomethane; isopentyl nitrite / toluene / 1 h / 25 - 80 °C

7.1: potassium carbonate / dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II) / tetrahydrofuran / 25 °C / Inert atmosphere

With N-Bromosuccinimide; diiodomethane; hydrogen; sodium hydride; potassium carbonate; isopentyl nitrite; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); 2,2'-azobis(isobutyronitrile); palladium 10% on activated carbon; In tetrahydrofuran; tetrachloromethane; ethanol; toluene; mineral oil;