1-{2-amino-6-[4-fluoro-5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo-[2,3-b]pyridin-3-yl]pyrimidin-4-yl}-1-(3-fluorophenyl)ethanol

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Chemical Name:1-{2-amino-6-[4-fluoro-5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo-[2,3-b]pyridin-3-yl]pyrimidin-4-yl}-1-(3-fluorophenyl)ethanol
CAS No.:1313021-31-6
Molecular Formula:C₂₃H₁₉F₂N₇O
Molecular Weight:447.447
Hs Code.:

Synonyms:1-{2-amino-6-[4-fluoro-5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo-[2,3-b]pyridin-3-yl]pyrimidin-4-yl}-1-(3-fluorophenyl)ethanol

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Chemical Property of 1-{2-amino-6-[4-fluoro-5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo-[2,3-b]pyridin-3-yl]pyrimidin-4-yl}-1-(3-fluorophenyl)ethanol

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Technology Process of 1-{2-amino-6-[4-fluoro-5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo-[2,3-b]pyridin-3-yl]pyrimidin-4-yl}-1-(3-fluorophenyl)ethanol

There total 14 articles about 1-{2-amino-6-[4-fluoro-5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo-[2,3-b]pyridin-3-yl]pyrimidin-4-yl}-1-(3-fluorophenyl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1313021-86-1
C₂₅H₂₃F₂N₇O₂

: 1313021-31-6
1-{2-amino-6-[4-fluoro-5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo-[2,3-b]pyridin-3-yl]pyrimidin-4-yl}-1-(3-fluorophenyl)ethanol

Guidance literature:: C₂₅H₂₃F₂N₇O₂; With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 2h;

With sodium hydrogencarbonate; In 1,4-dioxane; water;

Reference yield:

: 640735-25-7
4-fluoro-1-[tris(propan-2-yl)silyl]-1H-pyrrolo[2,3-b]pyridine

: 1313021-31-6
1-{2-amino-6-[4-fluoro-5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo-[2,3-b]pyridin-3-yl]pyrimidin-4-yl}-1-(3-fluorophenyl)ethanol

Guidance literature:: Multi-step reaction with 9 steps

1.1: sec.-butyllithium / tetrahydrofuran / 0.5 h / -70 - -65 °C / Inert atmosphere

1.2: 1 h / Inert atmosphere

2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 100 °C / Inert atmosphere

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

4.1: potassium hydroxide; iodine / N,N-dimethyl-formamide / 2 h / 20 °C

5.1: dmap; triethylamine / dichloromethane / 3 h / 20 °C

6.1: caesium carbonate / palladium diacetate; tri-tert-butyl phosphine / toluene; acetonitrile / 0.17 h / 80 °C

7.1: potassium carbonate; methanol / 1 h / 20 °C

8.1: potassium carbonate / 2-methoxy-ethanol / 3 h / 130 °C

9.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

With hydrogenchloride; methanol; dmap; tetrabutyl ammonium fluoride; iodine; sec.-butyllithium; sodium carbonate; potassium carbonate; caesium carbonate; triethylamine; potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tri-tert-butyl phosphine; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; 2-methoxy-ethanol; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 5-bromo-4-fluoro-1-[tris(propan-2-yl)silyl]-1H-pyrrolo[2,3-b]pyridine

: 1313021-31-6
1-{2-amino-6-[4-fluoro-5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo-[2,3-b]pyridin-3-yl]pyrimidin-4-yl}-1-(3-fluorophenyl)ethanol

Guidance literature:: Multi-step reaction with 8 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 100 °C / Inert atmosphere

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

3: potassium hydroxide; iodine / N,N-dimethyl-formamide / 2 h / 20 °C

4: dmap; triethylamine / dichloromethane / 3 h / 20 °C

5: caesium carbonate / palladium diacetate; tri-tert-butyl phosphine / toluene; acetonitrile / 0.17 h / 80 °C

6: potassium carbonate; methanol / 1 h / 20 °C

7: potassium carbonate / 2-methoxy-ethanol / 3 h / 130 °C

8: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

With hydrogenchloride; methanol; dmap; tetrabutyl ammonium fluoride; iodine; sodium carbonate; potassium carbonate; caesium carbonate; triethylamine; potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tri-tert-butyl phosphine; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; 2-methoxy-ethanol; N,N-dimethyl-formamide; toluene; acetonitrile;