2-chloro-N-(2-(cyclohexylamino)-2-oxo-1-(o-tolyl)ethyl)-N-(3-fluorophenyl)acetamide

Base Information

• Chemical Name: 2-chloro-N-(2-(cyclohexylamino)-2-oxo-1-(o-tolyl)ethyl)-N-(3-fluorophenyl)acetamide
• CAS No.: 1355324-97-8
• Molecular Formula: C₂₃H₂₆ClFN₂O₂
• Molecular Weight: 416.923

Synonyms:2-chloro-N-(2-(cyclohexylamino)-2-oxo-1-(o-tolyl)ethyl)-N-(3-fluorophenyl)acetamide

Chemical Property of 2-chloro-N-(2-(cyclohexylamino)-2-oxo-1-(o-tolyl)ethyl)-N-(3-fluorophenyl)acetamide

Chemical Property:

Purity/Quality:

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MSDS Files:

SDS file from LookChem

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Technology Process of 2-chloro-N-(2-(cyclohexylamino)-2-oxo-1-(o-tolyl)ethyl)-N-(3-fluorophenyl)acetamide

There total 2 articles about 2-chloro-N-(2-(cyclohexylamino)-2-oxo-1-(o-tolyl)ethyl)-N-(3-fluorophenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

meta-fluoroaniline (372-19-0) + Cyclohexyl isocyanide (931-53-3) + chloroacetic acid (79-11-8) + 2-methylphenyl aldehyde (529-20-4) → 2-chloro-N-(2-(cyclohexylamino)-2-oxo-1-(o-tolyl)ethyl)-N-(3-fluorophenyl)acetamide (1355324-97-8)

Guidance literature:

meta-fluoroaniline; 2-methylphenyl aldehyde; In methanol; at 20 ℃; for 0.666667h;

chloroacetic acid; In methanol; at 20 ℃; for 0.333333h;

Cyclohexyl isocyanide; In methanol; at 20 ℃; for 3h;

DOI:10.1021/ml300225h

Reference yield:

→ 2-chloro-N-(2-(cyclohexylamino)-2-oxo-1-(o-tolyl)ethyl)-N-(3-fluorophenyl)acetamide (1355324-97-8)

Guidance literature:

Reference yield: 82.0%

2-chloro-N-(2-(cyclohexylamino)-2-oxo-1-(o-tolyl)ethyl)-N-(3-fluorophenyl)acetamide (1355324-97-8) + 2-(2-fluoroethoxy)aniline (1547-11-1) → N-cyclohexyl-2-(2-((2-(2-fluoroethoxy)phenyl)amino)-N-(3-fluorophenyl)acetamido)-2-(o-tolyl)acetamide

Guidance literature:

In ethanol; for 16h; Reflux;

DOI:10.1016/j.bmcl.2018.01.015

upstream raw materials:

meta-fluoroaniline

Cyclohexyl isocyanide

chloroacetic acid

2-methylphenyl aldehyde

Downstream raw materials:

C₃₂H₃₆FN₃O₂

C₃₀H₃₄FN₃O₂

C₂₉H₃₀F₂N₂O₃

C₃₁H₃₄FN₃O₃

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