(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(2-nitrophenyl)propanoic acid

Base Information

Chemical Name:(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(2-nitrophenyl)propanoic acid
CAS No.:210282-30-7
Molecular Formula:C₂₄H₂₀N₂O₆
Molecular Weight:432.433
Hs Code.:2924297099
DSSTox Substance ID:DTXSID80943325
Wikidata:Q72478701
Mol file:210282-30-7.mol

Synonyms:210282-30-7;Fmoc-L-2-Nitrophenylalanine;Fmoc-2-Nitro-L-Phenylalanine;Fmoc-Phe(2-NO2)-OH;(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(2-nitrophenyl)propanoic acid;Fmoc-L-2-Nitrophe;(2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(2-nitrophenyl)propanoic acid;(2S)-2-({[(9H-FLUOREN-9-YL)METHOXY]CARBONYL}AMINO)-3-(2-NITROPHENYL)PROPANOIC ACID;SCHEMBL799728;DTXSID80943325;L-Phenylalanine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-2-nitro-;MFCD01317717;AKOS024464851;AM83441;Fmoc-L-2-nitrophenylalanine, AldrichCPR;PS-12518;CS-0179065;Fmoc-2-nitro-L-phenylalanine, 98% (HPLC);A50187;EN300-624045;(9H-Fluoren-9-yl)MethOxy]Carbonyl L-2-Nitrophe;Fmoc-L-2-nitrophenylalanine (Fmoc-L-Phe(2-NO2)-OH);Z2044772029;N-[(9H-fluoren-9-ylmethoxy)carbonyl]-2-nitro-L-phenylalanine;N-{[(9H-Fluoren-9-yl)methoxy](hydroxy)methylidene}-2-nitrophenylalanine

Suppliers and Price of (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(2-nitrophenyl)propanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Fmoc-2-nitro-L-phenylalanine
500mg
$ 333.00

TRC
Fmoc-L-2-nitrophenylalanine
1g
$ 110.00

Sigma-Aldrich
Fmoc-2-nitro-L-phenylalanine 98% (HPLC)
1g
$ 256.00

Matrix Scientific
Fmoc-2-nitro-L-phenylalanine
5g
$ 910.00

Matrix Scientific
Fmoc-2-nitro-L-phenylalanine
1g
$ 251.00

Crysdot
Fmoc-Phe(2-NO2)-OH 95+%
10g
$ 395.00

Chem-Impex
Fmoc-2-nitro-L-phenylalanine,99.5%(ChiralHPLC) 99.5%(ChiralHPLC)
25G
$ 1142.40

Chem-Impex
Fmoc-2-nitro-L-phenylalanine ≥ 99.5% (Chiral HPLC)
5G
$ 210.00

Chem-Impex
Fmoc-2-nitro-L-phenylalanine ≥ 99.5% (Chiral HPLC)
1G
$ 45.00

Chemenu
Fmoc-2-nitro-L-phenylalanine 95%
10g
$ 373.00

Total 35 raw suppliers

Chemical Property of (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(2-nitrophenyl)propanoic acid

Chemical Property:

Vapor Pressure:5.18E-19mmHg at 25°C
Refractive Index:1.649
Boiling Point:672.665 °C at 760 mmHg
PKA:3.58±0.11(Predicted)
Flash Point:360.615 °C
PSA：121.45000
Density:1.372 g/cm³
LogP:5.04330
Storage Temp.:Store at R.T.
XLogP3:4.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:7
Exact Mass:432.13213636
Heavy Atom Count:32
Complexity:673

Purity/Quality:

97% ^*data from raw suppliers

Fmoc-2-nitro-L-phenylalanine ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C(=C1)CC(C(=O)O)NC(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24)[N+](=O)[O-]
Isomeric SMILES:C1=CC=C(C(=C1)C[C@@H](C(=O)O)NC(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24)[N+](=O)[O-]

Technology Process of (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(2-nitrophenyl)propanoic acid

There total 1 articles about (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(2-nitrophenyl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 28920-43-6
(fluorenylmethoxy)carbonyl chloride

: 1991-82-8,35378-63-3,19883-75-1
(2S)-2-amino-3-(2-nitrophenyl)propanoic acid

: 210282-30-7,478183-70-9
(S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(2-nitrophenyl)propanoic acid

Guidance literature:: With sodium carbonate; In 1,4-dioxane; water; at 0 - 20 ℃; for 4h;
DOI:10.1021/jacs.1c02817

Reference yield: 47.0%

: 210282-30-7,478183-70-9
(S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(2-nitrophenyl)propanoic acid

: C₁₂H₁₈N₆O₃

: (9H-fluoren-9-yl)methyl (S)-1-((2S,3S,4R)-5-(6-(dimethylamino)-9H-purin-9-yl)-4-hydroxy-2- (hydroxymethyl)- tetrahydrofuran-3-ylamino)-3-(2-nitrophenyl)-1-oxopropan-2-ylcarbamate

Guidance literature:: With 1-hydroxy-pyrrolidine-2,5-dione; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 16h; Darkness; Inert atmosphere;
DOI:10.1021/jacs.1c02817

Reference yield:

: 210282-30-7,478183-70-9
(S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(2-nitrophenyl)propanoic acid

: (S)-2-amino-N-((2S,3S,4R)-5-(6-(dimethylamino)-9H-purin-9-yl)-4-hydroxy-2-(hydroxymethyl)-tetrahydrofuran-3-yl)-3-(2-nitrophenyl) propanamide

Guidance literature:: Multi-step reaction with 2 steps

1: 1-hydroxy-pyrrolidine-2,5-dione; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 16 h / 0 - 20 °C / Darkness; Inert atmosphere

2: morpholine / N,N-dimethyl-d₆-formamide / 2 h / 20 °C / Inert atmosphere; Darkness

With morpholine; 1-hydroxy-pyrrolidine-2,5-dione; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; N,N-dimethyl-d₆-formamide;
DOI:10.1021/jacs.1c02817