(3R)-3-(4,4-dimethyl-2-oxotetrahydrofuranyl) (E)-2-diazo-4-phenyl-3-butenoate

Base Information

Chemical Name:(3R)-3-(4,4-dimethyl-2-oxotetrahydrofuranyl) (E)-2-diazo-4-phenyl-3-butenoate
CAS No.:153062-67-0
Molecular Formula:C₁₆H₁₆N₂O₄
Molecular Weight:300.314
Hs Code.:

Synonyms:(3R)-3-(4,4-dimethyl-2-oxotetrahydrofuranyl) (E)-2-diazo-4-phenyl-3-butenoate

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Chemical Property of (3R)-3-(4,4-dimethyl-2-oxotetrahydrofuranyl) (E)-2-diazo-4-phenyl-3-butenoate

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Technology Process of (3R)-3-(4,4-dimethyl-2-oxotetrahydrofuranyl) (E)-2-diazo-4-phenyl-3-butenoate

There total 4 articles about (3R)-3-(4,4-dimethyl-2-oxotetrahydrofuranyl) (E)-2-diazo-4-phenyl-3-butenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 152978-83-1
(3R)-3-(4,4-dimethyl-2-oxotetrahydrofuranyl) (E)-4-phenyl-3-butenoate

: 153062-67-0
(3R)-3-(4,4-dimethyl-2-oxotetrahydrofuranyl) (E)-2-diazo-4-phenyl-3-butenoate

Guidance literature:: With 4-acetamidobenzenesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; for 1h;

Reference yield:

: 2243-53-0,59744-46-6,1914-58-5
trans-styrylacetic acid

: 153062-67-0
(3R)-3-(4,4-dimethyl-2-oxotetrahydrofuranyl) (E)-2-diazo-4-phenyl-3-butenoate

Guidance literature:: Multi-step reaction with 2 steps

1: DCC, DMAP / CH₂Cl₂ / 0.5 h / Ambient temperature

2: ABSA, DBU / acetonitrile / 0.5 h / Ambient temperature

With dmap; ABSA; 1,8-diazabicyclo[5.4.0]undec-7-ene; dicyclohexyl-carbodiimide; In dichloromethane; acetonitrile;
DOI:10.1021/jo961952j

Reference yield:

: 118575-70-5
trans-styrylacetyl chloride

: 153062-67-0
(3R)-3-(4,4-dimethyl-2-oxotetrahydrofuranyl) (E)-2-diazo-4-phenyl-3-butenoate

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine, 4-(N,N-dimethylamino)pyridine / CH₂Cl₂ / 12 h / Ambient temperature

2: 81 percent / p-acetamidobenzenesulfonyl azide, 1,8-diazabicyclo<5.4.0>undec-7-ene / acetonitrile / 1 h

With pyridine; dmap; 4-acetamidobenzenesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; acetonitrile;