5-(3-bromo-2-(hydroxymethyl)phenyl)-2-tert-butyl-4H-thieno[3,2-c]pyrrol-6(5H)-one

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Chemical Name:5-(3-bromo-2-(hydroxymethyl)phenyl)-2-tert-butyl-4H-thieno[3,2-c]pyrrol-6(5H)-one
CAS No.:1361941-10-7
Molecular Formula:C₁₇H₁₈BrNO₂S
Molecular Weight:380.305
Hs Code.:

Synonyms:5-(3-bromo-2-(hydroxymethyl)phenyl)-2-tert-butyl-4H-thieno[3,2-c]pyrrol-6(5H)-one

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Chemical Property of 5-(3-bromo-2-(hydroxymethyl)phenyl)-2-tert-butyl-4H-thieno[3,2-c]pyrrol-6(5H)-one

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Technology Process of 5-(3-bromo-2-(hydroxymethyl)phenyl)-2-tert-butyl-4H-thieno[3,2-c]pyrrol-6(5H)-one

There total 10 articles about 5-(3-bromo-2-(hydroxymethyl)phenyl)-2-tert-butyl-4H-thieno[3,2-c]pyrrol-6(5H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1361941-09-4
3-((3-Bromo-2-(hydroxymethyl)phenylamino)methyl)-5-tert-butylthiophene-2-carboxylic acid

: 1361941-10-7
5-(3-bromo-2-(hydroxymethyl)phenyl)-2-tert-butyl-4H-thieno[3,2-c]pyrrol-6(5H)-one

Guidance literature:: With benzotriazole-1-yl-oxy-tris-(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 16h; Inert atmosphere;

Reference yield:

: 81452-54-2
methyl 3-methylthiophene-2-carboxylate

: 1361941-10-7
5-(3-bromo-2-(hydroxymethyl)phenyl)-2-tert-butyl-4H-thieno[3,2-c]pyrrol-6(5H)-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: aluminum (III) chloride / dichloromethane / 0.17 h / -78 °C

1.2: 25.75 h / -78 - 20 °C

2.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 85 °C

3.1: caesium carbonate / acetonitrile / 16 h / 40 °C / Inert atmosphere

4.1: lithium hydroxide / ethanol; water; tetrahydrofuran / 2 h / 20 °C

4.2: pH 4

5.1: triethylamine; benzotriazole-1-yl-oxy-tris-(dimethylamino)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

With aluminum (III) chloride; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); benzotriazole-1-yl-oxy-tris-(dimethylamino)phosphonium hexafluorophosphate; caesium carbonate; triethylamine; lithium hydroxide; In tetrahydrofuran; tetrachloromethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 58579-54-7
3-bromo-2-(bromomethyl)-1-nitrobenzene

: 1361941-10-7
5-(3-bromo-2-(hydroxymethyl)phenyl)-2-tert-butyl-4H-thieno[3,2-c]pyrrol-6(5H)-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium acetate / N,N-dimethyl-formamide / 0.5 h / 70 °C / Inert atmosphere

2.1: lithium hydroxide monohydrate / ethanol; water; tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

3.1: ammonium chloride; iron / water / 1 h / 80 °C / Reflux

4.1: caesium carbonate / acetonitrile / 16 h / 40 °C / Inert atmosphere

5.1: lithium hydroxide / ethanol; water; tetrahydrofuran / 2 h / 20 °C

5.2: pH 4

6.1: triethylamine; benzotriazole-1-yl-oxy-tris-(dimethylamino)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

With lithium hydroxide monohydrate; benzotriazole-1-yl-oxy-tris-(dimethylamino)phosphonium hexafluorophosphate; potassium acetate; iron; ammonium chloride; caesium carbonate; triethylamine; lithium hydroxide; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; acetonitrile;